Recombinant Anti-CD27 Antibody (FITC), Rabbit Monoclonal

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Recombinant Anti-CD27 Antibody (FITC), Rabbit Monoclonal (Rabbit Monoclonal antibody) General Information

Product name
Recombinant Anti-CD27 Antibody (FITC), Rabbit Monoclonal
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human CD27
Immunogen
Recombinant Human CD27 / TNFRSF7 protein (Catalog#10039-H03H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human CD27 (rh CD27; Catalog#10039-H03H; Met 1-Ile 192; NP_001233.1) and conjugated with FITC under optimum conditions, the unreacted FITC was removed .
Source
Monoclonal Rabbit IgG Clone #023
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Recombinant Anti-CD27 Antibody (FITC), Rabbit Monoclonal (Rabbit Monoclonal antibody) Images

Flow cytometric analysis of anti-human CD27 on human whole blood lymphocytes. Human lymphocytes were stained with anti human CD27-R023 (solid line) or rabbit IgG isotype control (dashed line).

Recombinant Anti-CD27 Antibody (FITC), Rabbit Monoclonal: Synonyms

Anti-S152 Antibody; Anti-S152. LPFS2 Antibody; Anti-S152.LPFS2 Antibody; Anti-T14 Antibody; Anti-TNFRSF7 Antibody; Anti-Tp55 Antibody

CD27 Background Information

CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has important role in generation of T cell immunity, and is an apparently robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD7 on lymphocytes and dendritic cells. The CD27-CD7 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.
Full Name
CD27 molecule
Research Areas
References
  • Drner T, et al. (2004) Correlation of circulating CD27 high plasma cells and disease activity in systemic lupus erythematosus. Lupus. 13(5): 283-9.
  • Sahota SS, et al. (2009) CD27 in defining memory B-cell origins in Waldenstrm's macroglobulinemia. Clin Lymphoma Myeloma. 9(1): 33-5.
  • Jiang J, et al. (2010) Reduced CD27 expression on antigen-specific CD4+ T cells correlates with persistent active tuberculosis. J Clin Immunol. 30(4): 566-73.

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