Anti-Chromogranin A/CHGA Antibody, Rabbit Polyclonal

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Anti-Chromogranin A/CHGA Antibody, Rabbit Polyclonal (Rabbit Polyclonal antibody) General Information

Product name
Anti-Chromogranin A/CHGA Antibody, Rabbit Polyclonal
Validated applications
IHC-P
Species reactivity
Reacts with: Human
Specificity
Human Chromogranin A/CHGA
Immunogen
A synthetic peptide corresponding to the N-terminus of the human Chromogranin A.
Preparation
Produced in rabbits immunized with A synthetic peptide corresponding to the N-terminus of the human Chromogranin A., and purified by antigen affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Chromogranin A/CHGA Antibody, Rabbit Polyclonal (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
IHC-P 1:10000-1:20000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Chromogranin A/CHGA Antibody, Rabbit Polyclonal (Rabbit Polyclonal antibody) Images

Immunochemical staining of human ChromograninA in human pancreas with rabbit polyclonal antibody (1:20000, formalin-fixed paraffin embedded sections).
Immunochemical staining of human ChromograninA in human adrenal gland with rabbit polyclonal antibody (1:20000, formalin-fixed paraffin embedded sections).

Anti-Chromogranin A/CHGA Antibody, Rabbit Polyclonal: Synonyms

Anti-CGA Antibody

Chromogranin A/CHGA Background Information

The acidic glycoprotein chromogranin A (CHGA) is co-stored/co-secreted with catecholamines and crucial for secretory vesicle biogenesis in neuronal/neuroendocrine cells. CHGA is dysregulated in several cardiovascular diseases, but the underlying mechanisms are not well established. The CHGA promoter haplotype 2 (occurring in a large proportion of the world population) in enhancing CHGA expression in haplotype 2 carriers who may be at higher risk for cardiovascular/metabolic disorders. Chromogranin A (CHGA) plays a fundamental role in the biogenesis of catecholamine secretory granules. Changes in storage and release of CHGA in clinical and experimental hypertension prompted us to study whether genetic variation at the CHGA locus might contribute to alterations in autonomic function, and hence hypertension and its target organ consequences such as hypertensive renal disease (nephrosclerosis). Chromogranin A (CHGA) plays a catalytic role in formation of catecholamine storage vesicles and also serves as precursor to the peptide fragment catestatin, a catecholamine secretory inhibitor whose expression is diminished in the hypertensive individuals. The chromogranin/secretogranin proteins are costored and coreleased with catecholamines from secretory vesicles in chromaffin cells and noradrenergic neurons. Chromogranin A (CHGA) regulates catecholamine storage and release through intracellular (vesiculogenic) and extracellular (catecholamine release-inhibitory) mechanisms. CHGA is a candidate gene for autonomic dysfunction syndromes, including intermediate phenotypes that contribute to human hypertension.
Full Name
chromogranin A

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