Anti-DDX4 Antibody, Rabbit Polyclonal

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Anti-DDX4 Antibody, Rabbit Polyclonal (Rabbit Polyclonal antibody) General Information

Product name
Anti-DDX4 Antibody, Rabbit Polyclonal
Validated applications
IHC-P
Species reactivity
Reacts with: Human, Rat
Predicted to React with: Mouse (Species predicted to react based on 100% sequence homology)
Specificity
Human DDX4
Immunogen
A synthetic peptide corresponding to the C-terminus of the human DDX4
Preparation
Produced in rabbits immunized with A synthetic peptide corresponding to the C-terminus of the human DDX4, and purified by antigen affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-DDX4 Antibody, Rabbit Polyclonal (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
IHC-P 1:1000-1:5000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-DDX4 Antibody, Rabbit Polyclonal (Rabbit Polyclonal antibody) Images

Immunochemical staining DDX4 in human testis with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
Immunochemical staining DDX4 in rat testis with rabbit polyclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections.

Anti-DDX4 Antibody, Rabbit Polyclonal: Synonyms

Anti-VASA Antibody

DDX4 Background Information

DDX4 (DEAD box polypeptide 4), characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), is an RNA helicase which is implicated in various cellular processes involving the alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. DDX4 is known to be a germ cell-specific protein and is used as a sorting marker of germline stem cells for the production of oocytes. The active vitamin D treatment prohibited the proliferation and invasion of ovarian cancer cells, and the expression level of a germ cell specific marker DEAD (Asp-Glu-Ala-Asp)-box helicase 4 (DDX4), which is overexpressed in ovarian cancer, was downregulated by active vitamin D treatment. Knockdown of DDX4 by siRNA could also suppress the invasive ability of ovarian cancer cells. Therefore, DDX4 may be considered as a diagnostic marker of ovarian cancer, and vitamin D may be a candidate drug for ovarian cancer therapy. That DDX4 is essential for the regulation of germ cell proliferation and differentiation across all three extant mammalian groups-eutherians, marsupials, and monotremes.
Full Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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