Anti-ER alpha Antibody, Rabbit Polyclonal


Anti-ER alpha Antibody, Rabbit Polyclonal (Rabbit Polyclonal antibody) General Information

Product name
Anti-ER alpha Antibody, Rabbit Polyclonal
Validated applications
Species reactivity
Reacts with: Human
Human ER alpha
A synthetic peptide corresponding to the center region of the human ER alpha/ESR1
Produced in rabbits immunized with A synthetic peptide corresponding to the center region of the human ER alpha/ESR1, and purified by antigen affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-ER alpha Antibody, Rabbit Polyclonal (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
IHC-P 1:10000-1:20000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-ER alpha Antibody, Rabbit Polyclonal (Rabbit Polyclonal antibody) Images

Immunochemical staining of human ER alpha/ESR1 in human breast with rabbit polyclonal antibody (1:20000, formalin-fixed paraffin embedded sections).

Anti-ER alpha Antibody, Rabbit Polyclonal: Synonyms

Anti-ER Antibody; Anti-Era Antibody; Anti-ESR Antibody; Anti-ESRA Antibody; Anti-ESTRR Antibody; Anti-NR3A1 Antibody

ER alpha Background Information

An ESR1 gene mutation, which encodes for the estrogen receptor (ER) protein, is one of the potential mechanisms of therapy resistance. The ESR1 mutations result in conformational changes in the ER leading to subsequent estrogen-independent transcriptional activity. The mutations within the estrogen receptor (ER) gene, ESR1, frequently occur in metastatic breast cancer and influence response to hormone therapy. Estrogen receptor alpha (ERalpha) is one of the estrogen hormone-activated transcription factors, which regulates a large number of genes and is involved in the mammary gland development. Expression of ERalpha is considered to be a good indicator for endocrine therapy and breast cancer survival. Loss of ERalpha in breast cancer patients indicates invasiveness and poor prognosis. ESR1 as a direct target of miR-31a-3p and suggest that miR-31a-3p likely contributes to development of estrogen independence, which leads to a more invasive phenotype of breast cancer. Polymorphisms of the estrogen receptor gene alpha (ESR1) are consistently been associated with bone mineral density (BMD) and fracture.
Full Name
estrogen receptor 1
Related Pathways
  • MAPK-Erk Pathway
    MAPK-Erk Pathway

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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