Recombinant Anti-GITR Antibody, Rabbit Monoclonal

RRID Number: AB_2860438
EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-GITR Antibody, Rabbit Monoclonal General Information

Product name
Recombinant Anti-GITR Antibody, Rabbit Monoclonal
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human GITR
Immunogen
Recombinant Human GITR/TNFRSF18/CD357 Protein (Catalog#13643-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human GITR/TNFRSF18/CD357 (rh GITR/TNFRSF18/CD357; Catalog#13643-H08H; NP_683700.1; Met1-Glu161).
Source
Monoclonal Rabbit IgG Clone #002
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-GITR Antibody, Rabbit Monoclonal Validated Applications

Application Dilution
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-GITR Antibody, Rabbit Monoclonal: Synonyms

Anti-AITR Antibody; Anti-CD357 Antibody; Anti-GITR Antibody; Anti-GITR-D Antibody

GITR Background Information

GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.
Full Name
tumor necrosis factor receptor superfamily, member 18
Research Areas
References
  • Kwon B, et al. (1999) Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. J Biol Chem. 274(10):6056-61.
  • Nocentini G, et al. (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci. 94(12): 6216-21.
  • Baltz KM, et al. (2007) Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions. FASEB J. 21(10):2442-54.

Standard Antibody Development Service

Rabbit MAb

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Rabbit PAb

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Mouse MAb

Rabbit PAb

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