A synthetic peptide corresponding to the center region of the Human Glypican 3 / GPC3 / OCI-5
This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the center region of the Human Glypican 3 / GPC3 / OCI-5, and it was conjugated with PE under optimum conditions, the unreacted PE was removed.
Monoclonal Rabbit IgG Clone #024
Aqueous solution containing 0.5% BSA and 0.03%ProClin300
10 μl/Test, 0.1 mg/ml
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze !
Flow cytometric analysis of Human GPC3 expression on HepG2 cells. Cells were stained with PE-conjugated anti-Human GPC3. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Glypican-3, also known as Intestinal protein OCI-5, GPC3, and OCI5, is a member of the glypican family. It belongs to the glypican family and is highly expressed in lung, liver, and kidney. It is a heparan sulfate proteoglycan, which is overexpressed in various neoplasms such as hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an important role in cell growth and differentiation. GPC3 function is tissue dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. Studies have shown that GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceeds both alpha-fetoprotein and hepatocyte-paraffin1. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. The role of GPC3 in melanomas is still controversial. Thus, Glypican-3 is currently regarded as a tumor marker and potential target for immunotherapy.
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