Recombinant Anti-IL22 Antibody, Rabbit Monoclonal

RRID Number: AB_2860429
EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-IL22 Antibody, Rabbit Monoclonal General Information

Product name
Recombinant Anti-IL22 Antibody, Rabbit Monoclonal
Validated applications
ELISA,ELISA(Det)
Species reactivity
Reacts with: Human
Specificity
Human IL22
Immunogen
Recombinant Human IL22 / Interleukin 22 Protein (Catalog#13059-HNAE)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human IL22 / Interleukin 22 (rh IL22 / Interleukin 22; Catalog#13059-HNAE; NP_065386.1; Ala34-Ile179).
Source
Monoclonal Rabbit IgG Clone #034
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-IL22 Antibody, Rabbit Monoclonal Validated Applications

Application Dilution
ELISA 1:5000-1:10000
ELISA(Det) 1:1000-1:10000
Notes
ELISA(Det): This antibody will detect Human IL22 in ELISA pair set (Catalog: # SEK13059). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 13059-MM24).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-IL22 Antibody, Rabbit Monoclonal: Synonyms

Anti-IL-22 Antibody; Anti-IL-D110 Antibody; Anti-IL-TIF Antibody; Anti-ILTIF Antibody; Anti-TIFa Antibody; Anti-TIFIL-23 Antibody; Anti-zcyto18 Antibody

IL22 Background Information

IL22 is a member of a group of cytokines called the IL-1 family of IL-1 superfamily (including IL-19, IL-2, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. It shares the use of IL-1R2 in cell signaling with other members of this family, IL-1, IL-26, IL-28A/B, and IL-29. IL22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL22 along with IL-17 is rapidly produced by splenic LTi-like cells and can be also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems. IL22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-1R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (SIL-22R1). IL22 and IL-1 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. IL22 can contribute to immune disease through the stimulation of inflammatory responses, S1s, and defensins. IL22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-1. In some contexts, the pro-inflammatory versus tissue-protective functions of IL22 are regulated by the often co-expressed cytokine IL-17A.
Full Name
interleukin 22
References
  • Pestka S. et al., 2004, Annu Rev Immunol. 22: 929-79.
  • Xie MH. et al., 2000, J Biol Chem. 275 (40): 31335-9.
  • Jones BC. et al., 2008, Structure. 16 (9): 1333-44.

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