Anti-Smad2 Antibody, Rabbit Polyclonal

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Anti-Smad2 Antibody, Rabbit Polyclonal (Rabbit Polyclonal antibody) General Information

Product name
Anti-Smad2 Antibody, Rabbit Polyclonal
Validated applications
IHC-P
Species reactivity
Reacts with: Human, Mouse, Rat
Specificity
Human Smad2
Immunogen
A synthetic peptide corresponding to the center region of the Human Smad2
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human Smad2, and purified by antigen affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Smad2 Antibody, Rabbit Polyclonal (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
IHC-P 1:200-1:1000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Smad2 Antibody, Rabbit Polyclonal (Rabbit Polyclonal antibody) Images

Immunochemical staining SMAD2 in human skeletal muscle with rabbit polyclonal antibody (1:500, formalin-fixed paraffin embedded sections).
Immunochemical staining SMAD2 in mouse skeletal muscle with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.
Immunochemical staining SMAD2 in rat skeletal muscle with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.

Anti-Smad2 Antibody, Rabbit Polyclonal: Synonyms

Anti-hMAD-2 Antibody; Anti-hSMAD2 Antibody; Anti-JV18 Antibody; Anti-JV18-1 Antibody; Anti-MADH2 Antibody; Anti-MADR2 Antibody

Smad2 Background Information

SMAD2 is a member of the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD2 mediates the signal of the TGF-beta, and therefore regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. SMAD2 is the downstream signal transducers of TGF-beta-1 in human dental pulp cells. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. Phosphorylated SMAD2 is able to form a complex with SMAD4 or SARA. These complexes accumulate in the cell nucleus, where they are directly participating in the regulation of gene expression.
Full Name
SMAD family member 2
Related Pathways
  • TGF-beta Signaling
    TGF-beta Signaling
References
  • Feng. et al., 2002, Mol Cell. 9 (1): 133-43.
  • Zhu Y. et al., 1997, J Biol Chem. 272 (15): 10035-40.
  • Zi Z. et al., 2012, FEBS Lett. 586 (14): 1921-8.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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