Recombinant Anti-TrkB Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-TrkB Antibody, Rabbit Monoclonal (Rabbit Monoclonal antibody) General Information

Product name
Recombinant Anti-TrkB Antibody, Rabbit Monoclonal
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human TrkB
No cross-reactivity in ELISA with
Human Trk-A / NTRK1 / TRK
Human Trk-C / NTRK3 / TRKC
Mouse Trk-C / NTRK3 / TRKC
Immunogen
Recombinant Human Trk-B protein (Catalog#10047-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human NTRK2 / Trk-B extracellular domain (rh Trk-B; Catalog#10047-H08H; NP_001007098.1; Met 1-His 430).
Source
Monoclonal Rabbit IgG Clone #107
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-TrkB Antibody, Rabbit Monoclonal (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-TrkB Antibody, Rabbit Monoclonal: Synonyms

Anti-GP145-TrkB Antibody; Anti-GP145-TrkB/GP95-TrkB Antibody; Anti-Tkrb Antibody; Anti-trk-B Antibody; Anti-TRKB Antibody

TrkB Background Information

TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptors with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.
Full Name
neurotrophic tyrosine kinase, receptor, type 2
References
  • Klein R, et al. (1990) The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell. 61 (4): 647-56.
  • Rose CR, et al. (2003) Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells. Nature. 426 (6962): 74-8.
  • Yamada K, et al. (2004) Brain-derived neurotrophic factor/TrkB signaling in memory processes. J Pharmacol Sci. 91 (4): 267-70.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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