C4BPB cDNA Clone: Expression and Clone Vector / Plasmid

C4BPB cDNA / Gene Overview

C4BPB cDNA / gene is a gene with protein product which located on 1q32.1. The C4BPB gene is conserved in chimpanzee, Rhesus monkey, dog, and rat. 120 organisms have orthologs with human gene C4BPB.

More C4BPB reagents

C4BPB cDNA / Gene Function

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008]

C4BPB cDNA / Gene Sequence

LOCUS
HUMC4BINDB 1101 bp mRNA linear PRI 24-AUG-1993
DEFINITION
Human (clone A19) C4b-binding protein beta-chain mRNA, complete cds.
ACCESSION
L11245
VERSION
L11245.1

This sequence information is just for reference only.

C4BPB Family & Reagents

C4BPB Gene family reagents (Sushi domain containing)

Approved Symbol Reagent list
HP
SEZ6L2
SELE
CFB
SELP
IL2RA
PAPPA2
CFH
CD55
C7
Approved Symbol Reagent list
APOH
C6
TPO
CFHR2
CD46
F13B
CFHR1
SUSD4
CR2
SELL

C4BPB cDNA / Gene Alias

  • C4b binding protein
  • beta chain
  • complement component 4 binding protein
  • beta chain

C4BPB cDNA / Gene Expression

Biased expression in liver (RPKM 52.4) and ovary (RPKM 16.6)