Argininosuccinate lyase Proteins, Antibodies, cDNA Clones Research Reagents

All Argininosuccinate lyase reagents are produced in house and quality controlled, including 4 Argininosuccinate lyase Antibody, 32 Argininosuccinate lyase Gene, 2 Argininosuccinate lyase IP Kit, 1 Argininosuccinate lyase Lysate, 1 Argininosuccinate lyase Protein, 2 Argininosuccinate lyase qPCR. All Argininosuccinate lyase reagents are ready to use.

Argininosuccinate lyase Protein (1)

    Argininosuccinate lyase Antibody (4)

      Argininosuccinate lyase cDNA Clone (32)

      NM_021577.3

      In cloning vector

      In lentiviral vector

      Argininosuccinate lyase Lysate (1)

        Argininosuccinate lyase Background

        The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide (NO) production. Nitric oxide (NO) plays an established role in numerous physiological and pathological processes, but the specific cellular sources of NO in disease pathogenesis remain unclear, preventing the implementation of NO-related therapy. Argininosuccinate lyase (ASL) is the only enzyme able to produce arginine, the substrate for NO generation by nitric oxide synthase (NOS) isoforms. Induction of endogenous NO production by enterocytes with supplements that upregulate ASL expression and complement its substrates results in improved epithelial integrity and alleviation of colitis and of inflammation-associated colon cancer.

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