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BLK (Protein | Antibody | cDNA Clone | ELISA Kit)

All BLK reagents are produced in house and quality controlled, including 28 BLK Gene, 1 BLK Lysate, 1 BLK Protein, 2 BLK qPCR. All BLK reagents are ready to use.

BLK Protein (1)

    BLK cDNA Clone (28)

    BLK Lysate (1)

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      BLK Background

      Tyrosine-protein kinase Blk, also known as B lymphocyte kinase, p55-Blk and BLK, is a member of theprotein kinase superfamily, Tyr protein kinase family and SRC subfamily. BLK / p55-Blk is expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles. BLK / p55-Blk is a src-family protein tyrosine kinase specifically expressed in B-lineage cells of mice. The early onset of Blk expression during B-cell development in the bone marrow and the high expression levels of Blk in mature B cells suggest a possible important role of Blk in B-cell physiology. It is a modulator of beta-cells function, acting through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 which is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

      BLK References

      • Dymecki,S.M. et al., 1992, J Biol Chem. 267 (7):4815-23.
      • Drebin J.A. et al., 1995, Oncogene 10:477-86.
      • Islam K.B.et al., 1995, J. Immunol. 154:1265-72.
      • Texido,G. et al., 2000, Mol Cell Biol. 20 (4):1227-33.
      • Borowiec M. et al., 2009, Proc. Natl. Acad. Sci. USA. 106: 14460-5.

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