BRG1 Antibodies, cDNA Clones Research Reagents

All BRG1 reagents are produced in house and quality controlled, including 1 BRG1 Antibody, 2 BRG1 Gene. All BRG1 reagents are ready to use.

BRG1 Antibody (1)

    BRG1 cDNA Clone (2)


    In expression vector

    In expression vector

    BRG1 Background

    The gene encoding the ATPase of the chromatin remodeling SWI/SNF complexes SMARCA4 (BRG1) is often mutated or silenced in tumors, suggesting a role as tumor suppressor. A high expression of SMARCA4 is associated with aggressive tumors, a high expression of SMARCA2 is associated with benign differentiated tumors, suggesting that SMARCA4 and SMARCA2 play opposite roles in cancer. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. The absence of SMARCA4/BRG1 immunostaining proved very useful in the diagnosis of hypercalcemic small cell ovarian carcinoma.

    Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.