BRG1 Antibodies, cDNA Clones Research Reagents

All BRG1 reagents are produced in house and quality controlled, including 1 BRG1 Antibody, 2 BRG1 Gene. All BRG1 reagents are ready to use.

BRG1 Antibody (1)

    BRG1 cDNA Clone (2)

    NM_001128844.1

    In expression vector

    In expression vector

    BRG1 Background

    The gene encoding the ATPase of the chromatin remodeling SWI/SNF complexes SMARCA4 (BRG1) is often mutated or silenced in tumors, suggesting a role as tumor suppressor. A high expression of SMARCA4 is associated with aggressive tumors, a high expression of SMARCA2 is associated with benign differentiated tumors, suggesting that SMARCA4 and SMARCA2 play opposite roles in cancer. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. The absence of SMARCA4/BRG1 immunostaining proved very useful in the diagnosis of hypercalcemic small cell ovarian carcinoma.

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