Caspase-7 (Protein | Antibody | cDNA Clone | ELISA Kit)

All Caspase-7 reagents are produced in house and quality controlled, including 1 Caspase-7 Antibody, 17 Caspase-7 Gene, 1 Caspase-7 IP Kit, 1 Caspase-7 Protein, 1 Caspase-7 qPCR. All Caspase-7 reagents are ready to use.

Caspase-7 Protein (1)

    Caspase-7 Antibody (1)

      Caspase-7 cDNA Clone (17)

      NM_022260.3

      In cloning vector

      In lentiviral vector

      Caspase-7 qPCR Primer (1)

      Caspase-7 Background

      Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family. Caspases play a role in the signal transduction pathways of apoptosis, necrosis and inflammation. There are two major classes of caspases: initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-1,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the executioner caspases. Caspase 7 exists in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. Caspase 7 cannot be detected in the brain. Caspase 7 functions in the activation cascade of caspases responsible for apoptosis execution. It cleaves and activates sterol regulatory element binding proteins (SREBPs). It proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Overexpression promotes programmed cell death.

      Caspase-7 References

      • Riedl S J, et al. (2001) Structural basis for the inhibition of caspase-3 by XIAP. Cell. 104(5):791-800.
      • Roy N, et al. (1997) The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. 16(23):6914-25.
      • Deveraux Q L, et al. (1997) X-linked IAP is a direct inhibitor of cell-death proteases. Nature. 388(6639): 300-4.

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