CD30/TNFRSF8 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All CD30/TNFRSF8 reagents are produced in house and quality controlled, including 15 CD30/TNFRSF8 Antibody, 2 CD30/TNFRSF8 ELISA, 16 CD30/TNFRSF8 Gene, 4 CD30/TNFRSF8 Lysate, 5 CD30/TNFRSF8 Protein, 1 CD30/TNFRSF8 qPCR. All CD30/TNFRSF8 reagents are ready to use.

CD30/TNFRSF8 Protein (5)

    CD30/TNFRSF8 Antibody (15)

      CD30/TNFRSF8 ELISA Kit & Match Antibody ELISA Pair Set (2)

      CD30/TNFRSF8 cDNA Clone (16)

      NM_001243.3
      NM_009401.2

      In cloning vector

      In lentiviral vector

      XM_015442579.1

      In expression vector

      CD30/TNFRSF8 qPCR Primer (1)

      CD30/TNFRSF8 Lysate (4)

        CD30/TNFRSF8 Background

        CD3, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD3 protein is expressed by activated, but not resting, T and B cells. CD3 can regulate proliferation of lymphocytes and may also play an important role in human immunodeficiency virus replication. As a regulator of apoptosis, CD3 protein induces cell death or proliferation, depending on the cell type, and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. CD3 protein expression is upregulated in various hematological malignancies, including Reed-Sternberg cells in Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin's lymphomas (NHLs), and CD3 is also linked to leukocytes in patients with chronic inflammatory diseases, including lupus erythematosus, asthma, rheumatoid arthritis and atopic dermatitis (AD).

        CD30/TNFRSF8 References

        • Rossi FM, et al. (2001) CD30L up-regulates CD30 and IL-4 expression by T cells. FEBS Lett. 508(3): 418-22.
        • Trovato M, et al. (2001) Expression of CD30 ligand and CD30 receptor in normal thyroid and benign and malignant thyroid nodules. Thyroid. 11(7): 621-8.
        • Ekstrom ES, et al. (2001) Presence of CD30(+) and CD30L(+) cells in human placenta and soluble CD30 levels in cord blood are independent of maternal atopy. Placenta. 22(4): 372-9.
        • Tang C, et al. (2008) A novel role of CD30L/CD30 signaling by T-T cell interaction in Th1 response against mycobacterial infection. J Immunol. 181(9): 6316-27.
        • Sun X, et al. (2008) A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Gastroenterology. 134(2): 447-58.
        • Oflazoglu E, et al. (2009) Targeting CD30/CD30L in Oncology and Autoimmune and Inflammatory Diseases.Adv Exp Med Biol. 647: 174-85.

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