CD73 Proteins, Antibodies, cDNA Clones Research Reagents

NT5E (5'-Nucleotidase Ecto, also known as NT; eN; NT5; NTE; eNT; CD73; E5NT; CALJA), located on 6q14.3, is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, fruit fly, mosquito, M.oryzae, N.crassa, and frog. The gene produces a 63368 Da protein composed of 574 amino acids. The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. NT5E is ubiquitously expressed in the endometrium, ovary, and other tissues.

CD73 Protein (7)

    CD73 Antibody (15)

      CD73 cDNA Clone (52)


      CD73 Lysate (6)

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        CD73 Background

        5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surface of human T and B lymphocytes. CD73 catalyzes the conversion of purine and pyrimidine ribo- and deoxyribonucleoside monophosphates to the corresponding nucleosides. CD73 serves as a costimulatory molecule in activating T cells. CD73 generated adenosine functions in cell signaling in many physiologic systems, including intestinal epithelium, ischemic myocardium, and cholinergic synapses. CD73 might mediate lymphocyte-stromal cell interactions or condition the local microenvironment to facilitate lymphocyte development and/or function. In CD73-depleted cells, surface levels of the leukocyte adhesion molecules ICAM-1, VCAM-1, and E-selectin increase. CD73 produces extracellular adenosine, which then acts on G protein-coupled purinergic receptors to induce cellular responses. CD73 has also been reported to regulate the expression of pro-inflammatory molecules in mouse endothelium.

        CD73 References

        • Resta R. et al., 1997, Cell Signal. 9 (2): 131-9.
        • Yamashita Y. et al., 1998, Eur J Immunol. 28 (10): 2981-90.
        • Louis NA. et al., 2008, J Immunol. 180 (6): 4246-55.
        • Grünewald JK. et al., 2010, J Inflamm. 7 (1): 10.

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