Cdk6 Antibodies, cDNA Clones Research Reagents

CDK6 (Cyclin Dependent Kinase 6) is a protein coding gene located on human chromosome 7q21.2. CDK6 is also known as MCPH12 and PLSTIRE. The human CDK6 gene encodes a 36938 Da protein containing 326 amino acids. The CDK6 protein is ubiquitously expressed in placenta, bone marrow and other tissues. Among its related pathways are C-MYB transcription factor network and Small cell lung cancer. CDK6 is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. CDK4 is an important paralog of CDK6 gene. CDK6 is associated with some diseases, including Microcephaly 12, Primary, Autosomal Recessive and Primary Autosomal Recessive Microcephaly.

Cdk6 Antibody (1)

    Cdk6 cDNA Clone (3)

    NM_001145306.1

    In expression vector

    Cdk6 Background

    The cell-cycle kinase CDK6 has been recognized not only as a typical cyclin-dependent kinase but as a transcriptional regulator with properties distinct from those of its close homologue CDK4. CDK6 regulates the transcription of a number of genes and its effects may be dependent on or independent of its kinase activity. The transcriptional function of CDK6 is crucial for its role in promoting myeloid and lymphoid malignancies, including AML and ALL and is important in maintaining hematopoietic and leukemic stem cells. CDK6 contributes to tumor formation by regulating transcriptional responses in a stage-specific manner. In early stages CDK6 kinase induces a complex transcriptional program to block p53 in hematopoietic cells. Cells lacking CDK6 kinase function are required to mutate p53 to achieve a fully transformed immortalized state. CDK6 binds to the promoters of genes including the p53-antagonists PRMT5, PPM1D and MDM4.

    Cdk6 References

    • Bellutti F, et al. (2018) Cdk6 antagonizes p53-induced responses during tumorigenesis. Cancer Discov 8 (7): 884-897.

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