Chymotrypsin C Proteins, Antibodies, cDNA Clones Research Reagents

All Chymotrypsin C reagents are produced in house and quality controlled, including 3 Chymotrypsin C Antibody, 43 Chymotrypsin C Gene, 1 Chymotrypsin C Lysate, 1 Chymotrypsin C Protein, 1 Chymotrypsin C qPCR. All Chymotrypsin C reagents are ready to use.

Chymotrypsin C Protein (1)

    Chymotrypsin C Antibody (3)

      Chymotrypsin C cDNA Clone (43)

      Chymotrypsin C qPCR Primer (1)

      Chymotrypsin C Lysate (1)

        Chymotrypsin C Background

        Chymotrypsin C (abbreviated for CTRC), also known as caldecrin or elastase4, is a digestive enzyme of the peptidase S1 family. This enzyme is synthesized as an inactivate chymotrypsinogen. On cleavage by trypsin into two parts that activate each other by removing two small peptides in a trans-proteolysis, chymotrypsin C produced. N-linked glycosylation of human CTRC is required for efficient folding and secretion, however, the N-linked glycan is unimportant for enzyme activity or inhibitor binding. It has been proposed that CTRC is a key regulator of digestive zymogen activation and a physiological co-activator of digestive carboxypeptidases proCPA1 and proCPA2. Mutations that abolish activity or secretion of CTRC increase the risk for chronic pancreatitis. It's speculated that CTRC might regulate pancreatic cancer cell migration in relation to cytokeratin 18 expression. The pancreatic cancer cell migration ability was downregulated in pancreatic cancer Aspc-1 cells that overexpressed CTRC, whereas the cell migration ability was upregulated in Aspc-1 cells in which CTRC was suppressed.

        Chymotrypsin C References

        • Lacruz RS, et al. (2011) Chymotrypsin C (caldecrin) is associated with enamel development. J Dent Res. 90 (10): 1228-33.
        • Zhou J, et al. (2011) Chymotrypsin C mutations in chronic pancreatitis. J Gastroenterol Hepatol. 26 (8): 1238-46.
        • Wang H, et al. (2011) Effect of chymotrypsin C and related proteins on pancreatic cancer cell migration. Acta Biochim Biophys Sin (Shanghai). 43 (5): 362-71.

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