CXCL4/PF4 Proteins, Antibodies, cDNA Clones Research Reagents

PF4 (Platelet Factor 4) is a protein coding gene located on human chromosome 4q13.3. PF4 is also known as PF-4, CXCL4 and SCYB4. The human PF4 gene encodes a 10845 Da protein containing 101 amino acids. The PF4 protein is biasedly expressed in bone marrow, spleen and other tissue. Among its related pathways are Signaling by GPCR and Cell surface interactions at the vascular wall. PF4 is related to heparin binding and CXCR3 chemokine receptor binding. PF4V1 is an important paralog of PF4 gene. PF4 is associated with some diseases, including Intermediate Coronary Syndrome and Erythromelalgia.

CXCL4/PF4 Protein (1)

    CXCL4/PF4 Antibody (3)

      CXCL4/PF4 cDNA Clone (26)


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      CXCL4/PF4 Background

      Platelet factor 4 (PF4), also known as chemokine (C-X-C motif) ligand 4 (CXCL4), is a small cytokine belonging to the CXC chemokine family. CXCL4/PF4 is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, CXCL4/PF4 probably has a role in inflammation and wound repair. This protein is released during platelet aggregation. CXCL4/PF4 neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. CXCL4 is chemotactic for neutrophils and monocytes. It inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. CXCL4/PF4 is up-regulated in human liver fibrosis and that it plays a nonredundant, functional role in experimental liver fibrosis by mediating stellate cell proliferation, migration, and intrahepatic immune cell recruitment.

      CXCL4/PF4 References

      • Zaldivar MM, et al. (2010) CXC chemokine ligand 4 (Cxcl4) is a platelet-derived mediator of experimental liver fibrosis. Hepatology. 51(4): 1345-53.
      • Lasagni L, et al. (2007) PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion. Blood. 109(10): 4127-34.
      • Struyf S, et al. (2004) Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis. Circ Res. 95(9): 855-7.

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