DcR2/TRAIL R4 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

TNFRSF10D (TNF Receptor Superfamily Member 10d) is a protein coding gene located on human chromosome 8p21.3. TNFRSF10D is also known as DCR2, CD264, TRUNDD, TRAILR4, and TRAIL-R4. The human TNFRSF10D gene encodes a 41823 Da protein containing 386 amino acids. The TNFRSF10D protein is ubiquitously expressed in gall bladder, colon and other tissues. Among its related pathways are Cell surface interactions at the vascular wall and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. TNFRSF10D is related to transmembrane signaling receptor activity and TRAIL binding. TNFRSF10B is an important paralog of TNFRSF10D gene. TNFRSF10D is associated with some diseases, including Osteogenic Sarcoma and Lung Cancer.

All DcR2/TRAIL R4 Reagents

DcR2/TRAIL R4 Protein (5)

    DcR2/TRAIL R4 Antibody (13)

      DcR2/TRAIL R4 ELISA Kit & Match Antibody ELISA Pair Set (1)

      DcR2/TRAIL R4 cDNA Clone (26)

      NM_003840.3
      XM_001107922.1

      DcR2/TRAIL R4 qPCR Primer (1)

      DcR2/TRAIL R4 Lysate (5)

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        DcR2/TRAIL R4 Background

        Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), also known as TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4), CD264, and Decoy receptor 2, is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. TRAIL R4/CD264/TNFRSF10D is widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. TRAIL R4/CD264/TNFRSF10D is also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart. The signaling capacity of TRAIL R4 is similar to that of TRAIL R1 and TRAIL R2 with respect to NF-κB activation, but differs in its inability to induce apoptosis. TRAIL R4 retains a C-terminal element containing one third of a consensus death domain motif. Transient overexpression of TRAIL R4 in cells normally sensitive to TRAIL-mediated killing confers complete protection, suggesting that one function of TRAIL R4 may be inhibition of TRAIL cytotoxicity.

        DcR2/TRAIL R4 References

        • Degli-Esposti MA, et al. (1997) The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity. 7(6): 813-20.
        • Meng RD, et al. (2000) The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis. Mol Ther. 1(2): 130-44.
        • Bouralexis S, et al. (2003) Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy. Br J Cancer. 89(1): 206-14.

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