Elite Rabbit Monoclonal Antibodies (EliteRmab®)
Compared with classical mouse monoclonal antibodies, rabbit monoclonal antibodies typically have higher affinities and specificities for the antigens they recognize. Through the successful development of a 2nd-generation rabbit monoclonal antibody technology platform, Sino Biological is able to provide high quality antibodies with higher sensitivity and specificity to satisfy your research needs.
Rabbit monoclonal antibodies from Sino Biological are 100% made in-house and more than 80% of our portfolio is generated from immunization utilizing recombinant proteins produced in eukaryotic cells. Hence these antibodies recognize the native version of their prospective target antigens. If your specific antibody is not available in our current stock, custom services as described below are available for the production of rabbit monoclonal antibodies for your research needs.
Rabbit Monoclonal Antibody Production Service
Sino Biological has established a phage-display-based high-throughput rabbit monoclonal antibody development & production technology platform. Rabbit monoclonal antibodies are developed by generating an antibody library to rapidly and accurately obtain antibody genes and their corresponding sequences, which is more suitable for the long-term preservation of high affinity antibodies and the ability to produce them by recombinant technologies.
Rabbit monoclonal antibodies developed at Sino Biological are validated by multiple types of assays such as ELISA, WB, IHC, FACS, etc., and are tested for efficient binding in a variety of tissues and cell types. This thorough verification strategy allows for the optimization of success rates to yield antibodies conferring low background and high sensitivity characteristics.
More Antibody Production & Development ServicesQuote！
- • Recombinant Antibody Production Service
- • Standard Mouse Mab Production Service
- • Standard Rabbit Pab Production Service
- • Fast Rabbit Pab Production Service
- • Fast Mouse Mab Production Service
- • Phospho-Specific Antibody Production Service
- • ELISA Kit Development Service
- • Antigen Production Service
Rabbit MAb technology platform
In contrast to typical rabbit hybridoma technology, Sino Biological has built up an effective rabbit monoclonal antibody production platform based on our unparalleled expertise in phage display antibody library technology, including the generation of rabbit antibody libraries and selection of high affinity antigen-specific antibodies by phage display. Our platform has advantages include:
1. Optimized design of antibody gene primers;
2. scFv and Fab libraries with a capacity of more than 108;
3. Multiple selection methods to ensure high affinity antibodies capture;
4. Effective serum-free transient expression system to get stable and highly productive recombinant antibodies.
Antibody affinity is typically presented by the equilibrium dissociation constant (KD)between antibody and antigen, where lower KD suggestes higher affinity. Most mouse monoclonal antibodies have a KD value of 10-9M while the KD of rabbit monoclonal antibody can be as low as 10-11M.
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| Mouse MAb KD=4.950nM | Rabbit MAb KD=0.017nM |
Sino Biological rabbit MAbs are highly specific to their antigens and able to recognized unique epitopes, having little cross-reaction with other proteins. Below example shows the IHC result of Sino Biological rabbit MAb wihch has much lower background than rabbit polyclonal antibody and mouse monoclonal antibody from other companies.
| Sino biological cD71 rabbit MAb, placenta tissue IHC |
CD71 rabbit polyclonal antibody(Vendor A), placenta tissue IHC |
CD71 mouse MAb(Vendor B), placenta tissue IHC |
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Rabbit monoclonal antibodies provided by Sino Biological can be used for multiple applications including ELISA、FCM、IHC-P、WB、ICC/IF and IP.
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Sino Biological rabbit Mab assays A IHC on human stomach tissue B. ICC on cells C.FCM on cells D. WB on cells |
Mouse MAbs are not suitable for detection of mouse samples due to cross-reaction and high background from anti-mouse secondary antibodies Using rabbit primary antibodies, you can have a higher sensitivity with mouse antigens without interference from Ig cross-reactivity.
Rabbit MAbs against Human Antigens (part of the list)
| Catalog # | Species | Molecule | Application |
| 10084-R015 | Human | CD274 | ELISA, IHC-P |
| 10004-R511 | Human | ERBB2 | ELISA, ELISA(Cap), FCM, lCC/IF, IF |
| 10565-R102 | Human | CD226 | ELISA |
| 10231-R301-P | Human | LDLR | FCM |
| 10259-R110 | Human | FCGR2B | WB, IHC-P, IP |
| 10773-R023 | Human | ASGR1 | ELISA |
| 10004-R002 | Human | ERBB2 | ELISA, IHC-P, FCM, ICC/IF, IF |
| 10001-R021 | Human | EGFR | WB, ELISA, ELISA(Det), ICC/IF, IF, IP |
| 10694-R028 | Human | EpCAM | WB, ELISA, ELISA(Det), IHC-P, FCM, ICC/IF, IF, IP |
| 13909-R226 | Human | F8 | ELISA |
| 10005-R017 | Human | PVRL2 | ELISA |
| 10377-RD67 | Human | PDCD1 | ELISA, IHC-P |
| 10594-RM03 | Human | PCSK9 | ELISA |
| 10186-R125 | Human | BSG | WB, ELISA, IHC-P, FCM, ICC/IF, IF, IP |
| 10136-R111-P | Human | FLT1 | FCM |
| 10390-R024 | Human | HAVCR2 | ELISA, ELISA(Cap) |
| 10390-R108 | Human | HAVCR2 | ELISA |
| 11066-R105 | Human | VEGFA | ELISA |
| 11215-R107 | Human | LAMP1 | WB, ELISA, IHC-P, FCM, ICC/IF, IF, IP |
| 11235-R019 | Human | REG3A | ELISA, IHC-P |
| 10973-R111 | Human | vWF | ELISA, ELISA(Det), IHC-P |
| 11050-R412 | Human | NGF | ELISA |
| 11279-R021 | Human | CTNNB1 | ELISA, IHC-P, ICC/IF, IF, IP |
| 13908-R002 | Human | ASGR2 | ELISA, IHC-P, FCM, ICC/IF, IF |
| 10008-R064 | Human | VEGFA | ELlSA, ELISA(Det) |
| 100087-R013 | Human | FGF2 | HC-P |
| 10014-R101 | Human | FGF2 | ELISA |
| 100393-R024-F | Human | GPC3 | FCM |
| 100393-R024-P | Human | GPC3 | FCM |
| 10084-R001 | Human | CD274 | ELISA |
| 10231-R301-F | Human | LDLR | FCM |
| 10289-R102 | Human | LGALS3 | HC-P |
| 10400-R113 | Human | CD4 | EIISA, IHC-P |
| 10417-R006 | Human | TNFRSF1B | ELISA |
| 10980-R081 | Human | CD8A | HC-P |
| 11051-Rn208 | Human | HAVCR1 | ELISA |
| 12078-R001 | Human | GLA | W8, ELISA, IP |
| 10007-R104 | Human | CSF3 | ELISA |
| 10073-R001 | Human | CD14 | IHC-P |
| 10160-R005 | Human | CFD | ELISA |
| 10259-R112 | Human | FCGR2B | ELISA.ELISA(Det) |
| 10327-RM04 | Human | MMP9 | ELISA |
| 10995-R018 | Human | SerpinG1 | WB, ELISA, ELISA(Det), IP |
| 11031-R039 | Human | CD8B | HC-P |
| 11192-R179 | Human | CD68 | HC-P |
| 11996-R351 | Human | KIT | ELISA, IHC-P |
| 12163-R005 | Human | VSIG4 | ELISA, ELISA(Det) |
| 13908-R002-P | Human | ASGR2 | FCM |
| 100128-R001 | Human | CD79A | IHC-P |
| 100129-R101 | Human | KRT14 | WB, IHC-P, IP |
| 100254-R211 | Human | VIM | IHC-P |
Rabbit MAbs against Mouse Antigens (part of the list)
| Catalog # | Species | Molecule | Application |
| 50134-R001 | Mouse | CD4 | ELISA, IHC-P |
| 50086-R001 | Mouse | FCGR1 | ELISA, IHC-P |
| 50010-R401 | Mouse | CD274 | FCM |
| 50683-R036 | Mouse | AG02 | IHC-P, IP |
| 50010-R485 | Mouse | CD274 | FCM, ICC/IF, IF |
| 50191-R032 | Mouse | CD38 | EUSA, IHC-P |
| 50413-R001-P | Mouse | F3 | FCM |
| 50083-R103 | Mouse | ASGR1 | ELISA |
| 50129-R004 | Mouse | MSR1 | IHC-P, FCM, ICC/IF, IF |
| 50389-R208 | Mouse | CD8A | FCM.ICC/IFJF |
| 50067-R014 | Mouse | TNFSF9 | ELISA, FCM, ICC/IF, IF |
| 50083-R114 | Mouse | ASGR1 | IHC-P |
| 50469-R110 | Mouse | IFNAR1 | ICC/IF, IF |
| 50036-R011 | Mouse | FCGR4 | ELISA, IHC-P |
| 50073-R167 | Mouse | IL18 | ELISA, ELISA(Det) |
| 50128-R112-A | Mouse | TNFRSF1B | FCM |
| 50305-R032-P | Mouse | LDLR | FCM |
| 50413-R001 | Mouse | F3 | FCM |
| 50440-R020 | Mouse | ICAM1 | ELISA, ELISA[Cap), IHC-P |
| 50030-R005 | Mouse | Fcgr2 | ELISA |
| 50059-R220 | Mouse | CSF1R | ELISA |
| 50086-R008 | Mouse | FCGR1 | EUSA, IHC-P |
| 50086-R027 | Mouse | FCGR1 | FCM, ICC/IF, IF |
| 50110-R034 | Mouse | CD27 | ELISA |
| 50259-R305 | Mouse | PVR | FCM, ICC/IF, IF |
| 50279-R001 | Mouse | REN | ELISA, IHC-P |
| 50331-R038 | Mouse | ECM1 | ELISA |
| 50396-R034 | Mouse | GRN | ELISA, ELISA(Cap) |
| 50589-R013 | Mouse | CD34 | WB, ELISA, ELISA(Det), IHC-P, FCM, ICC/IF, IF, IP |
| 51179-R021 | Mouse | IL36G | ELISA |
| 50010-R485-P | Mouse | CD274 | FCM |
| 50061-R015 | Mouse | IL13Ra2 | ELISA |
| 50073-R169 | Mouse | IL18 | ELISA(Cap) |
| 50086-R027-F | Mouse | FCGR1 | FCM |
| 50114-R024 | Mouse | IL1A | ELISA |
| 50155-R277 | Mouse | CXCL9 | ELISA |
| 50256-R066 | Mouse | PDPN | IHC-P |
| 50362-R003 | Mouse | F9 | ELISA |
| 50389-R208-A | Mouse | CD8A | FCM |
| 50389-R208-F | Mouse | CD8A | FCM |
| 50412-R131 | Mouse | TNFRSF10B | ELISA |
| 50468-R076 | Mouse | CD55 | FCM, ICC/IF, IF |
| 50503-R037 | Mouse | CTLA4 | ELISA |
| 50537-R029 | Mouse | CD2 | ELISA, IHC-P |
| 50660-R001 | Mouse | CA9 | IHC-P |
| 50813-R048 | Mouse | SLC3A2 | IHC-P |
| 51091-R112 | Mouse | EGFR | ELISA |
| 50010-R485-A | Mouse | CD274 | FCM |
| 50023-R503 | Mouse | CD14 | FCM, ICC/IF, IF |
| 50087-R011-P | Mouse | IL2RG | FCM |
| 50110-R133 | Mouse | CD27 | ELISA |
Rabbit MAbs against Antigens of Other species (part of the list)
| Catalog # | Species | Molecule | Application |
| 11055-RM05 | Influenza | HA | WB, EUSA, IHC-P, FCM, ICC/IF, IF, IP |
| 11082-R002 | Influenza | HA | ELISA, ELlSA(Cop), FCM, B/N, Microneutralizai-ton(MN), Hemagglutininlnhibition(HI) |
| 86001-RM01 | Influenza | HA | WB, ELISA, IHC-P, FCM, ICC/IF, IF, IP |
| 11055-RM10 | Influenza | HA | WB, IHC-P, FCM, ICC/IF, IF, IP |
| 11058-R001 | Influenza | HA | WB, EUSA, IHC-P, FCM, ICC/IF, IF, IP |
| 40069-R723 | MERS-CoV | Spike | Microneutralizaiton(MN) |
| 80016-R005-F | Rat | FCGR1 | FCM |
| 80016-R015 | Rat | FCGR1 | ELISA |
| 80076-R007 | Rat | IL6 | ELISA |
| 80079-R187 | Rat | ERBB2 | ELISA |
| 11049-R009 | RSV | RSV-F | ELISA, IHC-P, FCM, ICC/IF, IF, IP |
| 13105-R208 | Aequorea victoria | GFP | WB, ELISA, IP |
| 11680-R112 | C.perfringens | NA | ELISA, IHC-P, FCM, ICC/IF, IF, IP |
| 70109-R039 | Canine | PDCD1 | ELISA |
| 70001-R202 | Canine | HAVCR1 | ELISA, IHC-P |
| 10202-R038 | CMV | gB | WB, EUSA, IHC-P, FCM, ICC/IF, IF, IP |
| 90001-R002 | Cynomolgus | TP53 | IHC-P, ICC/IF, IF |
| 90014-R046 | Cynomolgus | FCGR2B | ELISA |
| 40094-R106 | EBOV | EBOV-G | WB, EUSA, IHC-P, FCM, ICC/IF, IF, IP |
| 40094-R301 | EBOV | EBOV-G | ELfSA, IHC-P, FCM, lCC/IF, IF, IP |
| 60004-R071 | Ferret | MS4A1 | ELISA |
| 60001-R073-A | Ferret | CD8A | FCM |
| 60002-R030 | Ferret | TNF | ELISA |
| 40359-R137 | H10N8 | HA | ELISA, IHC-P, FCM, ICC/IF, IF, IP |
| 11684-R016 | H1N1 | HA | ELISA(Cap), IHC-P, FCM |
| 11056-R006 | H3N2 | HA | ELISA, IHC-P, FCM, ICC/IF, IF, IP |
| 11056-R104 | H3N2 | HA | ELISA, IHC-P, FCM, ICC/IF, IF, IP |
| 11056-R014 | H3N2 | HA | ELISA(Cap) |
| 11048-RM01 | H5N1 | HA | WB, EUSA, IHC-P, FCM, ICC/IF, IF, IP |
| 40021-R028 | HCoV | Spike | ELISA, IHC-P, FCM, ICC/IF, IF, IP |
| 11233-R011 | HIV | gp120 | WB, ELISA, ELlSA(Det), IHC-P, FCM, lCC/IF, IF, IP |
| 11695-R002 | HIV | Gag-p24 | WB, ELISA, IHC-P, FCM, ICC/IF, IF, IP |
| 11233-R001 | HIV | gp120 | ELISA, ELlSA(Cap), IHC-P, FCM, lCC/IF, IF, IP |
