FABP4 Proteins, Antibodies, cDNA Clones Research Reagents

All FABP4 reagents are produced in house and quality controlled, including 5 FABP4 Antibody, 30 FABP4 Gene, 2 FABP4 Lysate, 5 FABP4 Protein, 2 FABP4 qPCR. All FABP4 reagents are ready to use.

FABP4 Protein (5)

    FABP4 Antibody (5)

      FABP4 cDNA Clone (30)

      FABP4 Lysate (2)

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        FABP4 Background

        Fatty acid-binding protein, adipocyte, also known as Adipocyte-type fatty acid-binding protein, Fatty acid-binding protein 4, Adipocyte lipid-binding protein, and FABP4, is a cytoplasm protein which belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. In familial combined hyperlipidemia (FCHL), FABP4 correlated to body mass index (BMI), waist circumference and homeostasis model assessment (HOMA) index.FABP4 levels were associated with triglyceride-rich lipoproteins. In humans serum FABP4 levels correlate significantly with features of PCOS. It appears to be a determinant of atherogenic dyslipidemia. FABP4 pathway mediates the sebaceous gland hyperplasia in keratinocyte-specific Pten-null mice. FABP4 concentration significantly increased with an increasing of MS features and was strongly correlated with body-mass index, triglycerides, HDL-cholesterol concentrations and blood pressure. Patients in the highest quartile of FABP4 presented a six-fold increased odds ratio for MS and a three-fold increased odds for LD, adjusted by age, sex, body-mass index and the antiretroviral therapy. FABP4 is a strong plasma marker of metabolic disturbances in HIV-infected patients, and therefore, could serve to guide therapeutic intervention in this group of patients.

        FABP4 References

        • van Dongen,M.J. et al., 2002, J Am Chem Soc. 124 (40): 11874-80.
        • Coll, B. et al., 2008, Atherosclerosis  199 (1):147-53.
        • Hoashi,S. et al., 2008, BMC Genet. 9 :84.
        • Cai,H. et al., 2010, Bioorg Med Chem Lett  20 (12):3675-9.

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