FNDC4 Proteins, Antibodies, cDNA Clones Research Reagents

All FNDC4 reagents are produced in house and quality controlled, including 1 FNDC4 Antibody, 26 FNDC4 Gene, 1 FNDC4 Lysate, 1 FNDC4 Protein, 2 FNDC4 qPCR. All FNDC4 reagents are ready to use.

FNDC4 Protein (1)

    FNDC4 Antibody (1)

      FNDC4 cDNA Clone (26)


      FNDC4 Lysate (1)

        FNDC4 Background

        FNDC4 acts as an anti-inflammatory factor on macrophages and improves mouse model of induced colitis. FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10. Analysis of binding of FNDC4 to different immune cell types reveals strong and specific binding to macrophages and monocytes. FNDC4 treatment of bone marrow-derived macrophages in vitro results in reduced phagocytosis, increased cell survival and reduced proinflammatory chemokine expression. Hence, treatment with FNDC4 results in a state of dampened macrophage activity, while enhancing their survival. That FNDC4 may be a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases.

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