Glypican 3 Proteins, Antibodies, cDNA Clones Research Reagents

GPC3 (Glypican 3, also known as SGB; DGSX; MXR7; SDYS; SGBS; OCI-5; SGBS1; GTR2-2), located on Xq26.2, is a Protein Coding gene. The gene produces a 65563 Da protein composed of 580 amino acids. Members of the glypican family, including GPC3, are heparan sulfate proteoglycans that bind to the exocytoplasmic surface of the plasma membrane through a covalent glycosylphosphatidylinositol (GPI) linkage. GPC3 plays an important role in cell growth and differentiation. Diseases such as Simpson-Golabi-Behmel Syndrome, Type 1, and Wilms Tumor 1 are associated with GPC3.

Glypican 3 Protein (5)

    Glypican 3 Antibody (7)

      Glypican 3 cDNA Clone (22)


      In lentiviral vector


      Glypican 3 Lysate (4)

        Glypican 3 Background

        Glypican-3, also known as Intestinal protein OCI-5, GPC3, and OCI5, is a member of the glypican family. It belongs to the glypican family and is highly expressed in the lung, liver, and kidney. It is a heparan sulfate proteoglycan, which is overexpressed in various neoplasms such as hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an important role in cell growth and differentiation. GPC3 function is tissue-dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. Studies have shown that GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceed both alpha-fetoprotein and hepatocyte-paraffin1. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. The role of GPC3 in melanomas is still controversial. Thus, Glypican-3 is currently regarded as a tumor marker and potential target for immunotherapy.

        Glypican 3 References

        • Kandil DH, et al. (2009) Glypican-3: a novel diagnostic marker for hepatocellular carcinoma and more. Adv Anat Pathol. 16(2): 125-9.
        • Maeda D, et al. (2009) Glypican-3 expression in clear cell adenocarcinoma of the ovary. Mod Pathol. 22(6): 824-32.

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