HAI-2/SPINT2 Proteins, Antibodies, cDNA Clones Research Reagents

SPINT2 (Serine Peptidase Inhibitor, Kunitz Type 2) is a protein coding gene located on human chromosome 19q13.2. SPINT2 is also known as PB, Kop, HAI2, DIAR3, and HAI-2. The human SPINT2 gene encodes a 28228 Da protein containing 252 amino acids. The SPINT2 protein is broadly expressed in colon, thyroid and other tissues. Among its related pathways are Signaling by GPCR and MET promotes cell motility. SPINT2 is related to serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity. SPINT1 is an important paralog of SPINT2 gene. SPINT2 is associated with some diseases, including Diarrhea 3, Secretory Sodium, Congenital, With Or Without Other Congenital Anomalies and Syndromic Congenital Sodium Diarrhea.

HAI-2/SPINT2 Protein (3)

    HAI-2/SPINT2 Antibody (6)

      HAI-2/SPINT2 cDNA Clone (26)

      NM_021102.2
      NM_001082548.1

      HAI-2/SPINT2 Lysate (3)

        HAI-2/SPINT2 Background

        Choanal (CA) and gastrointestinal atresias (GA) are an important feature of syndromic congenital sodium diarrhea (sCSD), a disorder recently associated with mutations in the gene for serine protease inhibitor type 2 (SPINT2). The SPINT2 gene is epigenetically silenced or downregulated in human cancers, altering the balance of HGF activation/inhibition ratio, which contributes to cancer development and progression. SPINT2 is a tumor suppressor gene that inhibits proteases implicated in cancer progression, like HGFA, hepsin and matriptase. Loss of SPINT2 expression in tumors has been associated with gene promoter hypermethylation. SPINT2 (serine peptidase inhibitor Kunitz type 2), a proteolytic inhibitor of hepatocyte growth factor activator (HGFA), has a significant role in the suppression of the HGF-MET pathway and malignant melanoma progression.

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