ICAM4 Proteins, cDNA Clones Research Reagents

All ICAM4 reagents are produced in house and quality controlled, including 14 ICAM4 Gene, 1 ICAM4 Lysate, 1 ICAM4 Protein, 1 ICAM4 qPCR. All ICAM4 reagents are ready to use.

ICAM4 Protein (1)

    ICAM4 cDNA Clone (14)

    BC000046
    NM_023892.2

    In expression vector

    ICAM4 qPCR Primer (1)

    ICAM4 Lysate (1)

      ICAM4 Background

      ICAM4, also known as CD242, is a member of the?immunoglobulin superfamily, ICAM family. ICAM4 contains 2?Ig-like C2-type (immunoglobulin-like) domains. It is similar to the intercellular adhesion molecule (ICAM) protein family. ICAM4 binds to the leukocyte adhesion LFA-1 protein. ICAM4's first reported receptors were CD11a/CD18 and CD11b/CD18. ICAM4 functions as a ligand for the monocyte/macrophage-specific CD11c/CD18. Deletion of the individual immunoglobulin domains of ICAM4 demonstrated that both its domains contain binding sites for CD11c/CD18. CD11c/CD18 is expressed on macrophages in spleen and bone marrow. Inhibition of erythrophagocytosis by anti-ICAM4 and anti-integrin antibodies suggests a role for these interactions in removal of senescent red cells.

      ICAM4 References

      • Gorst DW. et al., 1980, Vox Sanguinis. 38 (2): 99-105.
      • Vos GH. et al., 1973, Blood. 42 (3): 445-53.
      • Kim W. et al., 2011, Mol Cell. 44 (2): 325-40.
      • Daniels G. et al., 2002, Transfusion Medicine. 12 (5): 287-95.

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