ICOS Proteins, cDNA Clones Research Reagents

ICOS (Inducible T Cell Costimulator, also known as AILIM; CD278; CVID1), located on 2q33.2, is a Protein Coding gene. The gene produces a 22625 Da protein composed of 199 amino acids. The ICOS gene encodes inducible T-cell costimulator, a receptor found on the surface of T cells. The corresponding ligand is encoded by the ICOSLG gene. ICOS amino acid sequence shares 24% and 17% identity, respectively, with CD28 and CTLA4. Diseases such as Immunodeficiency, Common Variable, 1, and Common Variable Immunodeficiency are associated with ICOS.

ICOS Protein (10)

    ICOS cDNA Clone (40)


    In cloning vector

    ICOS Lysate (7)

      ICOS Background

      Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4, and PD-1. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T−B cell interactions which are essential for the germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. Also, ICOS is more potent in the induction of IL-10 production, a cytokine important for the suppressive function of T regulatory cells. The B7-1/B7-2--CD28/CTLA-4 and ICOS-B7RP-1 pathway provide key second signals that can regulate the activation, inhibition, and fine-tuning of T-lymphocyte responses. ICOS stimulates both Th1 and Th2 cytokine production but may have a preferential role in Th2 cell development. Moreover, The B7-1/B7-2-CD28/CTLA-4 and ICOS-B7RP-1 pathway has been suggested as being involved in the development of airway inflammation and airway hyperresponsiveness.

      ICOS References

      • Coyle AJ, et al. (2004) The role of ICOS and other costimulatory molecules in allergy and asthma. Springer Semin Immunopathol. 25(3-4): 349-59.
      • Chen YQ, et al. (2006) CD28/CTLA-4--CD80/CD86 and ICOS--B7RP-1 costimulatory pathway in bronchial asthma. Allergy. 61(1): 15-26.
      • van Berkel ME, et al. (2006) CD28 and ICOS: similar or separate costimulators of T cells Immunol Lett. 105(2): 115-22.

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