IGF1 Proteins, Antibodies, cDNA Clones Research Reagents

IGF1 (Insulin-Like Growth Factor 1, also known as IGF; MGF; IGFI; IGF-I), located on 12q23.2, is a Protein Coding gene. The gene produces a 21841 Da protein composed of 195 amino acids. IGF I is a secreted protein that belongs to the insulin family. It mediates many of the growth-promoting effects of growth hormone. IGF1 may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Diseases such as Insulin-Like Growth Factor I and Pituitary Gland Disease are associated with IGF1.

IGF1 Protein (4)

    IGF1 Antibody (2)

      IGF1 cDNA Clone (65)

      NM_001111283.2
      NM_000618.4
      NM_010512.4
      NM_001082479.1
      NM_001313855.1

      IGF1 qPCR Primer (2)

      IGF1 Background

      IGF I, also known as Mechano Growth Factor, somatomedin-C, IGF-I, and IGF1, is a secreted protein that belongs to the insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ), and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also about enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness, and mental retardation.

      IGF1 References

      • Jansen M., et al.,(1983), Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature 306:609-611.
      • de Pagter-Holthuizen P., et al., (1986), Organization of the human genes for insulin-like growth factors I and II.FEBS Lett. 195:179-184.
      • le Bouc Y., et al.,(1986), Complete characterization of the human IGF-I nucleotide sequence isolated from a newly constructed adult liver cDNA library.FEBS Lett. 196:108-112.

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