IL-22BP Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL22RA2 (Interleukin 22 Receptor Subunit Alpha 2, also known as CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2; ZCYTOR16; IL-22R-alpha-2), located on 6q23.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish. The gene produces a 30550 Da protein composed of 263 amino acids. IL22RA2 encodes a soluble class II cytokine receptor and naturally occurring IL22 antagonist. It belongs to the class II cytokine receptor family. The related pathways of IL22RA2 include Th17 cell differentiation and the Innate Immune System.

IL-22BP Protein (4)

    IL-22BP Antibody (5)

      IL-22BP ELISA Kit & Match Antibody ELISA Pair Set (1)

      IL-22BP cDNA Clone (52)


      IL-22BP Lysate (4)

        IL-22BP Background

        Interleukin-22 receptor subunit alpha-2 (IL-22RA2), also known as interleukin-22-binding protein (IL-22BP), is a subunit of the receptor for interleukin 22. IL-22BP belongs to the type II cytokine receptor family and contains 3 fibronectin type-III domains. IL-22BP/IL-22RA2 is expressed in a range of tissues, including those in the digestive, female reproductive, and immune systems. It is expressed in the placenta, spleen, breast, skin, and lung. It is also detected in the intestinal tract, testis, brain, heart, and thymus. The dominant cell types expressing IL-22BP/IL-22RA2 were mononuclear cells and epithelium. IL-22BP/IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses. Interleukin-22 (IL-22) is a member of the IL-10 family. It is produced by T cells and induces the production of acute-phase reactants. IL-22 plays important role in the immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptors have been discovered, a membrane-bound receptor and a soluble receptor.

        IL-22BP References

        • Whittington HA, et al. (2004) Interleukin-22: a potential immunomodulatory molecule in the lung. Am J Respir Cell Mol Biol. 31(2): 220-6.
        • Dumoutier L, et al. (2001) Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. J Immunol. 166(12): 7090-5.
        • Wei CC, et al. (2003) Cloning and characterization of mouse IL-22 binding protein. Genes Immun. 4(3): 204-11.

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