IL17F Proteins, Antibodies, cDNA Clones Research Reagents

IL17F (Interleukin 17F, also known as ML1; ML-1; CANDF6; IL-17F), located on 6p12.2, is a Protein Coding gene. The gene produces a 18045 Da protein composed of 163 amino acids. IL17F is a cytokine that shares sequence similarity with IL17. The most notable role of IL17 is that it participates in inducing and mediating pro-inflammatory responses. Diseases such as Candidiasis, Familial, 6, and Chronic Mucocutaneous Candidiasis are associated with IL17F. The related pathways of IL17F include Immune response IL-23 signaling pathway and IL-17 Family Signaling Pathways.

IL17F Protein (6)

    IL17F Antibody (7)

      IL17F cDNA Clone (35)


      In expression vector

      In lentiviral vector


      In lentiviral vector

      In expression vector


      In cloning vector

      IL17F Lysate (3)

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        IL17F Background

        Interleukin-17F (IL-17F) is a cytokine that shares sequence similarity with IL17. The most notable role of IL-17 is its involvement in inducing and mediating proinflammatory responses. IL-17 is commonly associated with allergic responses. IL-17F is expressed by activated T cells and was expressed only in activated CD4+ T cells and activated monocytes. IL-17F has been shown to stimulate the production of several other cytokines, including IL6 and IL8. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. Recombinant human IL-17F did not stimulate the proliferation of hematopoietic progenitors or the migration of mature leukocytes. However, it markedly inhibited the angiogenesis of human endothelial cells and induced endothelial cells to produce IL-2, TGF-{beta}, and monocyte chemoattractant protein-1. IL-17F stimulates the production of other cytokines and granulocyte colony-stimulating factor and can regulate cartilage matrix turnover. IL-17F stimulates PBMC and T-cell proliferation. It also functions in inhibiting angiogenesis By similarity. IL-17F plays a role in the induction of neutrophilia in the lungs and the exacerbation of antigen-induced pulmonary allergic inflammation.

        IL17F References

          et al..
        • Starnes T, et al.. (2001) Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J Immunol. 167(8): 4137-40.
        • Hymowitz SG, et al.. (2001) IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J. 20(19): 5332-41.
        • McAllister F, et al.. (2005) Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. J Immunol. 175(1): 404-12.

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