IL20RB Proteins, Antibodies, cDNA Clones Research Reagents

IL20RB (Interleukin 20 Receptor Subunit Beta, also known as DIRS1; FNDC6; IL-20R2), located on 3q22.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. The gene produces a 35076 Da protein composed of 311 amino acids. IL20RB and IL20RA form a heterodimeric receptor for interleukin-20 (IL20). Human IL24 interacts with both IL20RA/IL20RB and IL22RA/IL20RB heterodimers. The related pathways of IL20RB include AKT Signaling Pathway and PEDF Induced Signaling.

IL20RB Protein (6)

    IL20RB Antibody (6)

      IL20RB cDNA Clone (50)

      NM_144717.3
      NM_001033543.3
      NM_001173438.1
      NM_001194658.1

      IL20RB Lysate (6)

        IL20RB Background

        IL20RB belongs to the type II cytokine receptor family. There are two kinds of type II cytokine receptors: cytokine receptors that bind type I and type II interferons; cytokine receptors that bind members of the interleukin-10 family (interleukin-10, interleukin-20, and interleukin-22). Type II cytokine receptors are similar to type I cytokine receptors except they do not possess the signature sequence WSXWS that is characteristic of type I receptors. They are expressed on the surface of certain cells, which bind and respond to a select group of cytokines. These receptors are related predominantly by sequence similarities in their extracellular portions that are composed of tandem Ig-like domains. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase belonging to the Janus kinase (JAK) family. IL20RB and IL20RA form a heterodimeric receptor for interleukin-20.

        IL20RB References

        • Zhu H, et al. (2009) Expression pattern of mda-7/IL-24 receptors in liver cancer cell lines. Hepatobiliary Pancreat Dis Int. 8(4):402-6.
        • Logsdon NJ, et al. (2012) Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 68(Pt 1):89-92.
        • Kingo K, et al. (2008) Association analysis of IL20RA and IL20RB genes in psoriasis. Genes Immun. 9(5):445-51.

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