IL22 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL22 (Interleukin 22, also known as TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23), located on 12q15, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. The gene produces a 20011 Da protein composed of 179 amino acids. This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. Diseases such as Scleritis and Intestinal Tuberculosis are associated with IL22. The related pathways of IL22 include PEDF Induced Signaling and Th17 cell differentiation.

IL22 Protein (2)

    IL22 Antibody (6)

      IL22 ELISA Kit & Match Antibody ELISA Pair Set (2)

      IL22 cDNA Clone (29)

      BC069308

      In expression vector

      In lentiviral vector

      NM_016971.1
      NM_001191988.1

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      IL22 Background

      IL22 is a member of a group of cytokines called the IL-1 family of IL-1 superfamily (including IL-19, IL-2, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. It shares the use of IL-1R2 in cell signaling with other members of this family, IL-1, IL-26, IL-28A/B, and IL-29. IL22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL22 along with IL-17 is rapidly produced by splenic LTi-like cells and can be also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems. IL22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-1R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (SIL-22R1). IL22 and IL-1 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. IL22 can contribute to immune disease through the stimulation of inflammatory responses, S1s, and defensins. IL22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-1. In some contexts, the pro-inflammatory versus tissue-protective functions of IL22 are regulated by the often co-expressed cytokine IL-17A.

      IL22 References

      • Pestka S. et al., 2004, Annu Rev Immunol. 22: 929-79.
      • Xie MH. et al., 2000, J Biol Chem. 275 (40): 31335-9.
      • Jones BC. et al., 2008, Structure. 16 (9): 1333-44.

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