Interferon alpha 2/IFNA2 Proteins, Antibodies, cDNA Clones Research Reagents

IFNA2 (Interferon Alpha 2, also known as IFNA; IFNA2B; Leif A; IFN-alphaA; IFN-alpha-2), located on 9p21.3, is a Protein Coding gene. The gene produces a 21550 Da protein composed of 188 amino acids. This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. The three principal subtypes of IFNα-2 are designated α-2a, α-2b, and α-2c. Diseases such as Hepatitis C and Peyronie's Disease are associated with IFNA2. The related pathways of IFNA2 include all-trans-retinoic Acid Mediated Apoptosis and Tuberculosis.

Interferon alpha 2/IFNA2 Protein (6)

    Interferon alpha 2/IFNA2 Antibody (5)

      Interferon alpha 2/IFNA2 cDNA Clone (39)

      NP_000596.2
      NM_010503.2
      NM_001135794.1

      Interferon alpha 2/IFNA2 Lysate (3)

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        Interferon alpha 2/IFNA2 Background

        IFNA2 (Interferon Alpha 2) is a Protein Coding gene. This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Type I Interferons (IFNs) are well-known cytokines that exert antiviral activity, antitumor activity, and immunomodulatory effects. Interferon tau (IFNT), a type I IFN similar to alpha IFNs (IFNA), is the pregnancy recognition signal produced by the ruminant conceptus. Among the IFN-α genes, a total of 28 different sequence variants have been described. The three principal subtypes of IFNα-2 are designated α-2a, α-2b, and α-2c. IFNα-2b is being the predominant allele while IFNα-2a is less predominant and IFNα-2c only a minor allelic variant.

        Interferon alpha 2/IFNA2 References

        • Wang, et al. (2004) Fever of recombinant human interferon-alpha is mediated by opioid domain interaction with opioid receptor inducing prostaglandin E2. J Neuroimmunol. 156(1-2): 107-12.
        • Groopman JE, et al. (1984) Recombinant alpha-2 interferon therapy for Kaposi's sarcoma associated with the acquired immunodeficiency syndrome. Ann Intern Med. 100(5): 671-6.
        • Krueger JM, et al. (1987) Interferon alpha-2 enhances slow-wave sleep in rabbits. Int J Immunopharmacol. 9(1): 23-30.

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