JAM-2/JAM-B Proteins, Antibodies, cDNA Clones Research Reagents

JAM2 (Junctional Adhesion Molecule 2, also known as JAMB; CD322; IBGC8; JAM-B; VEJAM; PRO245; VE-JAM; C21orf43), located on 21q21.3, is a Protein Coding gene. The gene produces a 33207 Da protein composed of 298 amino acids. JAM2 appears to contribute to leukocyte extravasation by facilitating not only transmigration but also rolling and adhesion. The type I transmembrane protein is 80% identical to the mouse protein. Diseases such as Basal Ganglia Calcification, Idiopathic, 8, Autosomal Recessive, and Pulsating Exophthalmos are associated with JAM2.

JAM-2/JAM-B Protein (4)

    JAM-2/JAM-B Antibody (4)

      JAM-2/JAM-B cDNA Clone (39)


      JAM-2/JAM-B Lysate (4)

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        JAM-2/JAM-B Background

        Junctional adhesion molecule B (JAM-B), also known as Junctional adhesion molecule 2 (JAM2), Vascular endothelial junction-associated molecule (VE-JAM), and CD322, is a single-pass type I membrane protein that belongs to the immunoglobulin superfamily. It is prominently expressed on high endothelial venules. expression to be restricted to the high endothelial venule of tonsil and lymph nodes. The localization to the endothelium of arterioles in and around inflammatory and tumor foci. JAM-B can function as an adhesive ligand for the T cell line J45 and can interact with GM-CSF/IL-4-derived peripheral blood dendritic cells, circulating CD56(+) NK cells, circulating CD56(+)CD3(+) NK/T cells, and circulating CD56(+)CD3(+)CD8(+) cytolytic T cells. JAM-2 is expressed on high endothelial venules (HEVs) in human tonsil and on a subset of human leukocytes, suggesting that JAM-2 plays a central role in the regulation of transendothelial migration. It binds to very late activation antigen (VLA)-4, a leucocyte integrin that contributes to rolling and firm adhesion of lymphocytes to endothelial cells through binding to vascular cell adhesion molecule (VCAM)-1. JAM-B appears to contribute to leukocyte extravasation by facilitating not only transmigration but also rolling and adhesion. JAM-B acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.

        JAM-2/JAM-B References

        • Johnson-Lger CA, et al. (2002) Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration. Blood. 2100(7): 2479-86.
        • Liang TW, et al. (2002) Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3. J Immunol. 168(4): 1618-26.
        • Ludwig RJ, et al. (2009) Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha4beta1 integrin. Immunology. 128(2): 196-205.

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