Kallikrein 6 Proteins, Antibodies, cDNA Clones Research Reagents

KLK6 (Kallikrein Related Peptidase 6, also known as hK6; Bssp; Klk7; SP59; PRSS9; PRSS18), located on 19q13.41, is conserved in Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 26856 Da protein composed of 244 amino acids. This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Diseases such as Breast Cyst and Postpoliomyelitis Syndrome are associated with KLK6. The related pathways of KLK6 include Collagen chain trimerization and MSP-RON Signaling.

Kallikrein 6 Protein (2)

    Kallikrein 6 Antibody (2)

      Kallikrein 6 cDNA Clone (26)


      Kallikrein 6 Lysate (2)

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        Kallikrein 6 Background

        KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease that exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein, and extracellular matrix proteins such as fibronectin, laminin, vitronectin, and collagen. KLK6 degrades alpha-synuclein and prevents its polymerization, indicating that KLK6 may be involved in the pathogenesis of Parkinson's disease and other synucleinopathies. Klk7 may be involved in the regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.

        Kallikrein 6 References

        • Krenzer S, et al. (2011) Expression and function of the kallikrein-related peptidase 6 in the human melanoma microenvironment. J Invest Dermatol. 131(11):2281-8.
        • Nathalie HV, et al. (2009) High kallikrein-related peptidase 6 in non-small cell lung cancer cells: an indicator of tumour proliferation and poor prognosis. J Cell Mol Med. 13(9B):4014-22.
        • Kim JT, et al. (2011) Up-regulation and clinical significance of serine protease kallikrein 6 in colon cancer. Cancer. 117(12):2608-19.
        • Scarisbrick IA, et al. (2011) Functional role of kallikrein 6 in regulating immune cell survival. PLoS One. 6(3):e18376.

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