Kininogen 1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

KNG1 (Kininogen 1, also known as BK; BDK; KNG; HMWK), located on 3q27.3, is a Protein Coding gene. The gene produces a 71957 Da protein composed of 644 amino acids. The KNG1 gene generates both HMWK and low molecular weight kininogen (LMWK) through alternative splicing. HMWK plays an important role in the assembly of the plasma kallikrein-kinin system. Diseases such as High Molecular Weight Kininogen Deficiency and Angioedema are associated with KNG1. The related pathways of KNG1 include RET signaling and Formation of Fibrin Clot (Clotting Cascade).

Kininogen 1 Protein (2)

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      Kininogen 1 ELISA Kit & Match Antibody ELISA Pair Set (1)

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        Kininogen 1 Background

        Kininogen-1, also known as high molecular weight kininogen, Williams-Fitzgerald-Flaujeac factor, Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, KNG1, and BDK, is a secreted protein that contains three cystatin domains. Kininogen-1 / KNG1 is a protein from the blood coagulation system as well as the kinin-kallikrein system. It is a protein that adsorbs to the surface of biomaterials that come in contact with blood. Kininogen-1 / KNG1 circulates throughout the blood and quickly adsorbs to the material surfaces. Kininogen-1 / KNG1 is one of the early participants of the intrinsic pathway of coagulation, together with Factor XII (Hageman factor) and prekallikrein. Kininogen-1 / KNG1 is one of the kininogens, a class of proteins. As with many other coagulation proteins, the protein was initially named after the patients in whom deficiency was first observed. When the clinical data were combined, it turned out that all patients had a deficiency of the same protein. Defects in KNG1 are the cause of high molecular weight kininogen deficiency (HMWK deficiency) which is an autosomal recessive coagulation defect. Patients with HWMK deficiency do not have a hemorrhagic tendency, but they exhibit abnormal surface-mediated activation of fibrinolysis.

        Kininogen 1 References

        • Ohkubo I., et al.,(1984), Isolation of a human cDNA for alpha 2-thiol proteinase inhibitor and its identity with low molecular weight kininogen. Biochemistry 23:5691-5697.
        • Takagaki Y., et al., (1985), Cloning and sequence analysis of cDNAs for human high molecular weight and low molecular weight prekininogens. Primary structures of two human prekininogens.J. Biol. Chem. 260:8601-8609.
        • Ota T., et al.,(2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.

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