LAMP1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

LAMP1 (Lysosomal Associated Membrane Protein 1, also known as LAMPA; CD107a; LGP120), located on 13q34, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish. The gene produces a 44882 Da protein composed of 417 amino acids. The protein encoded by this gene is a member of a family of membrane glycoproteins. LAMP1 has been implicated in a variety of cellular functions, including cancer metastasis. Diseases such as Chediak-Higashi Syndrome and Salla Disease are associated with LAMP1. The related pathways of LAMP1 include Lysosome and Tuberculosis.

LAMP1 Protein (2)

    LAMP1 Antibody (8)

      LAMP1 ELISA Kit & Match Antibody ELISA Pair Set (1)

      LAMP1 cDNA Clone (26)

      NM_005561.3
      NM_012857.1

      LAMP1 qPCR Primer (2)

      LAMP1 Lysate (2)

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        LAMP1 Background

        Lysosome-associated membrane glycoprotein 1, also known as CD107 antigen-like family member A, CD107a, and LAMP1, is a single-pass type I membrane protein that belongs to the LAMP family. CD107a is expressed largely in the endosome-lysosome membranes of cells but is also found on the plasma membrane (1-2% of total LAMP1). LAMP1 has been implicated in a variety of cellular functions, including cancer metastasis. It has been proposed LAMP1 serves as a therapeutic agent for some cancers, as well as a marker for lysosomal storage disorders and different cell types such as cytotoxic T cells. LAMP2, also known as CD107b, may also play a role in tumor cell metastasis and functions in the protection, maintenance, and adhesion of the lysosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation. LAMP-1 is a glycoprotein highly expressed in lysosomal membranes. The present study was initiated to test LAMP-1 mRNA and protein levels in post mortem frontal cortex (area 8) of Alzheimer's disease (AD) stages I-IIA/B and stages V-VIC of Braak and Braak, compared with age-matched controls. LAMP-1 occurred in microglia and multinucleated giant cells in one AD case in which amyloid burden was cleared following beta A-peptide immunization. Also, LAMP-1 has been suggested to be a cell surface receptor for a specific amelogenin isoform, leucine-rich amelogenin peptide, or LRAP. LAMP-1 can serve as a cell surface binding site for amelogenin on dental follicle cells and cementoblasts.

        LAMP1 References

        • Parkinson-Lawrence EJ, et al. (2005) Immunochemical analysis of CD107a (LAMP-1). Cell Immunol. 236(1-2): 161-6.
        • Barrachina M, et al. (2006) Lysosome-associated membrane protein 1 (LAMP-1) in Alzheimer's disease. Neuropathol Appl Neurobiol. 32(5): 505-16.
        • Zhang H, et al. (2010) Full length amelogenin binds to cell surface LAMP-1 on tooth root/periodontium associated cells. Arch Oral Biol. 55(6): 417-25.

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