LRIG1 Proteins, Antibodies, cDNA Clones Research Reagents

All LRIG1 reagents are produced in house and quality controlled, including 1 LRIG1 Antibody, 26 LRIG1 Gene, 1 LRIG1 Lysate, 1 LRIG1 Protein, 1 LRIG1 qPCR. All LRIG1 reagents are ready to use.

LRIG1 Protein (1)

    LRIG1 Antibody (1)

      LRIG1 cDNA Clone (26)


      LRIG1 qPCR Primer (1)

      LRIG1 Lysate (1)

        LRIG1 Background

        Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a tumor suppressor and a negative regulator of several receptor tyrosine kinases.Leucine-rich repeats and immunoglobulin-like domains containing protein 1 (LRIG1) is an endogenous feedback regulator of receptor tyrosine kinases (RTKs) and was recently shown to inhibit growth of different types of malignancies.Leucine-rich repeats and immunoglobulin-like domains 1(LRIG1)is a kind of transmembrane glycoprotein,which is induced by epidermal growth factor (EGF),and develops inhibitory negative feedback by specific binding with epidermal growth factor receptor (EGFR). LRIG1 expression is broadly decreased in human cancer and in breast cancer and low expression of LRIG1 has been linked to decreased relapse-free survival.

        LRIG1 References

        • Shattuck DL, et al. (2007) LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy. Mol Cell Biol. 27 (5): 1934-46.
        • Ledda F, et al. (2008) Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF. J Neurosci. 28(1): 39-49.
        • Hedman H, et al. (2002) Is LRIG1 a tumour suppressor gene at chromosome 3p14.3 Acta Oncol. 41(4): 352-4.

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