Germinal Center Kinase/MAP4K2 Proteins, cDNA Clones Research Reagents

All Germinal Center Kinase/MAP4K2 reagents are produced in house and quality controlled, including 2 Germinal Center Kinase/MAP4K2 Gene, 1 Germinal Center Kinase/MAP4K2 Lysate, 1 Germinal Center Kinase/MAP4K2 Protein, 1 Germinal Center Kinase/MAP4K2 qPCR. All Germinal Center Kinase/MAP4K2 reagents are ready to use.

Germinal Center Kinase/MAP4K2 Protein (1)

    Germinal Center Kinase/MAP4K2 cDNA Clone (2)

    BC047865

    In expression vector

    In lentiviral vector

    Germinal Center Kinase/MAP4K2 qPCR Primer (1)

    Germinal Center Kinase/MAP4K2 Lysate (1)

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      Germinal Center Kinase/MAP4K2 Background

      Mitogen-activated protein kinase kinase kinase kinase 2, also known as B lymphocyte serine/threonine-protein kinase, Germinal center kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, Rab8-interacting protein and MAP4K2, is a cytoplasm and peripheral membrane protein which belongs to theprotein kinase superfamily, STE Ser/Thr protein kinase family and STE2 subfamily. MAP4K2 contains oneCNH domain and oneprotein kinase domain. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. MAP4K2 can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. It is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1 / MEKK1. MAP4K2 enhances MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. It may also play a role in the regulation of vesicle targeting or fusion.

      Germinal Center Kinase/MAP4K2 References

      • Katz P, et al.,1994, J Biol Chem 269 (24): 16802-9.
      • Ren, M; et al., 1996,  Proc. Natl. Acad. Sci. USA. 93 (10): 5151-5.
      • Chadee D.N., et al., 2002, Mol. Cell. Biol. 22:737-49.
      • Wissing J., et al., 2007, Mol. Cell. Proteomics 6:537-47.
      • Oppermann F.S., et al., 2009, Mol. Cell. Proteomics 8:1751-64.

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