METAP1 Proteins, Antibodies, cDNA Clones Research Reagents

METAP1 (Methionyl Aminopeptidase 1, also known as MAP1A; MetAP1A), located on 4q23, is a Protein Coding gene. The gene produces a 43215 Da protein composed of 386 amino acids. s a member of the M24 family of metalloproteases, METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents. Diseases such as Microsporidiosis are associated with METAP1. The related pathways of METAP1 include Signaling by GPCR and Metabolism of fat-soluble vitamins.

METAP1 Protein (2)

    METAP1 Antibody (2)

      METAP1 cDNA Clone (32)

      NM_001106476.1

      In cloning vector

      In lentiviral vector

      METAP1 Lysate (2)

        METAP1 Background

        Processing of the N-terminal initiator methionine or formylated methionine is an essential cellular process conserved from prokaryotes to eukaryotes. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. As a member of the M24 family of metalloproteases, METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents.

        METAP1 References

          1. Lowther, W.T. and B.W. Matthews, 2000, Biochim. Biophys. Acta. 1477: 157 – 167.

          2. Addlaqatta, A. et al., 2005, Biochemistry. 44: 14741-14749.

          3. Hu, X. et al., 2006, Proc. Natl. Acad. Sci. U.S.A. 103:18148-18153.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.