NELL2 Proteins, Antibodies, cDNA Clones Research Reagents

NELL2 (Neural EGFL Like 2, also known as NRP2), located on 12q12, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 91346 Da protein composed of 816 amino acids. The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. During development, NELL2 appears to function as a repulsive guidance cue for commissural axons, helping to steer them across the spinal cord midline. Diseases such as Pediatric Infratentorial Ependymoma and Pediatric Ependymoma are associated with NELL2.

NELL2 Protein (1)

    NELL2 Antibody (3)

      NELL2 cDNA Clone (13)


      NELL2 qPCR Primer (1)

      NELL2 Lysate (1)

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        NELL2 Background

        A brain-enriched secreting signal peptide, NELL2, has been suggested to play multiple roles in the development, survival, and activity of neurons in the mammal. NELL2 is an abundant glycoprotein containing an EGF-like domain in the neural tissues where it has multiple physiological functions by interacting with protein kinase C (PKC). There are two different splicing variant forms of NELL2 identified so far. One is secreted NELL2 (sNELL2) which is a neuron-specific variant and the other is cytosolic NELL2 (cNELL2) which is a non-secreted splicing variant of NELL2. NELL2 is strongly expressed in the brain of adults and fetuses but only weakly in the fetal kidney.

        NELL2 References

        • Kuroda S, et al. (1999) Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2. Biochem Biophys Res Commun. 265(1): 79-86.
        • Oyasu M, et al. (2000) Immunocytochemical localization of a neuron-specific thrombospondin-1-like protein, NELL2: light and electron microscopic studies in the rat brain. Brain Res Mol Brain Res. 76(1): 151-60.
        • Nelson BR, et al. (2002) Restricted neural epidermal growth factor-like like 2 (NELL2) expression during muscle and neuronal differentiation. Mech Dev. 119 Suppl 1: 11-9.

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