NKG2D Proteins, Antibodies, cDNA Clones Research Reagents

KLRK1 (Killer Cell Lectin Like Receptor K1, also known as KLR; CD314; NKG2D; NKG2-D; D12S2489E), located on 12p13.2, is a Protein Coding gene. The gene produces a 25274 Da protein composed of 216 amino acids. KLRK1 belongs to the C-type lectin family. It is an activating receptor that triggers natural killer (NK) cells and costimulates CD8-positive alpha (TCRA)/beta (TCRB) T cells but is normally absent from almost all CD4-positive T cells. Diseases such as Cowpox and Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia are associated with KLRK1.

NKG2D Protein (4)

    NKG2D Antibody (3)

      NKG2D cDNA Clone (41)

      NM_007360.2
      NM_001083322.2

      In cloning vector

      In lentiviral vector

      NM_133512.1
      NM_001032889.1

      NKG2D qPCR Primer (2)

      NKG2D Lysate (4)

        NKG2D Background

        KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular proteins incapable to transduce signals. To transduce signals, NKG2D needs adaptor proteins and it uses two adaptor proteins, DAP10 and DAP12. These two adaptor proteins associate as homodimers to NKG2D- therefore the entire receptor complex appears as a hexamer. NKG2D can send co-stimulatory signals to activate CD8 T cells. NKG2D also plays an important role in viral control. Cellular stress can induce ligands for NKG2D which results in the cell susceptible to NK cell-mediated lysis.

        NKG2D References

        • Houchins J, et al. (1991) DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J Exp Med. 173: 1017-102.
        • Bauer S, et al. (1999) Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science. 285(5428):727-9.
        • Zafirova B, et al. (2011) Regulation of immune cell function and differentiation by the NKG2D receptor. Cell Mol Life Sci. 68(21):3519-29.

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