NKp46/NCR1 Proteins, Antibodies, cDNA Clones Research Reagents

NCR1 (Natural Cytotoxicity Triggering Receptor 1, also known as LY94; CD335; NKP46; NK-p46), located on 19q13.42, is a Protein Coding gene. The gene produces a 34481 Da protein composed of 304 amino acids. NCR1 encodes a type I transmembrane protein. The extracellular region is preceded by a 21-residue signal peptide with 2 cysteine-bridged C2-type Ig-like domains. Diseases such as Newcastle Disease and Hydatidiform Mole, Recurrent, 1 are associated with NCR1. The related pathways of NCR1 include the Immune response Role of DAP12 receptors in NK cells and Hematopoietic Stem Cells and Lineage-specific Markers.

NKp46/NCR1 Protein (2)

    NKp46/NCR1 Antibody (2)

      NKp46/NCR1 cDNA Clone (39)


      NKp46/NCR1 Lysate (2)

        NKp46/NCR1 Background

        NCR1, also known as NK-p46 and CD335, is a natural cytotoxicity receptor(NCR). NCRs are type I transmembrane proteins with 1-2 extracellular immunoglobulin domains, a transmembrane domain containing a positively charged amino acid residue, and a short cytoplasmic tail. All are expressed almost exclusively by NK cells and play a major role in triggering NK-mediated killing of most tumor cell lines. NKp46 has two extracellular Ig-like domains followed by a ~40 residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NKp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells, pathogen-infected cell lines, and mononuclear phagocytes infected with an intracellular bacterium.

        NKp46/NCR1 References

        • Carbone E, et al. (2005) HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells. Blood. 105(1):251-8.
        • Sivori S, et al. (1997) p46, a Novel Natural Killer Cell-specific Surface Molecule That Mediates Cell Activation. J Exp Med. 186(7):1129-36.
        • Biassoni R, et al. (2004) Human natural killer cell receptors: insights into their molecular function and structure. J Cell Mol Med. 7(4):376-87.

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