NPC2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All NPC2 reagents are produced in house and quality controlled, including 12 NPC2 Antibody, 1 NPC2 ELISA, 39 NPC2 Gene, 1 NPC2 IP Kit, 3 NPC2 Lysate, 3 NPC2 Protein, 3 NPC2 qPCR. All NPC2 reagents are ready to use.

NPC2 Protein (3)

    NPC2 Antibody (12)

      NPC2 ELISA Kit & Match Antibody ELISA Pair Set (1)

      NPC2 cDNA Clone (39)


      NPC2 Lysate (3)

        NPC2 Background

        Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding with free cholesterol. NPC2 is an intralysosomal protein that binds cholesterol in vitro. NPC2 is a small lysosomal glycoprotein that binds cholesterol with submicromolar affinity. Deficiency in NPC2 is the cause of Niemann-Pick type C2 disease, a fatal neurovisceral disorder characterized by accumulation of cholesterol in lysosomes.Niemann-Pick disease, type C2 (NPC2) protein is one of the most abundant components of the epididymal fluid and contains a functional cholesterol-binding site that can transfer cholesterol between membranes, it has been suggested for years that NPC2 could be involved in the regulation of cholesterol levels in spermatozoa during epididymal maturation.

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