Nonstructural protein 1/NS1 Proteins, cDNA Clones Research Reagents

The non-structural (NS1) protein of influenza A virus is a non-essential virulence factor that has multiple accessory functions during viral infection. NS1 protein can be divided into N-terminal (RNA binding) domain and C-terminal (effector domain). The major role ascribed to NS1 has been its inhibition of host immune responses, especially the limitation of both interferon (IFN) production and the antiviral effects of IFN-induced proteins. NS1 can not only significantly affect metabolism, but also slow down cell proliferation by blocking the cell cycle.

Nonstructural protein 1/NS1 Protein (1)

    Nonstructural protein 1/NS1 cDNA Clone (15)

    A/Puerto Rico/8/34/Mount Sinai

    Nonstructural protein 1/NS1 Background

    The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the NS2 protein, which mediates the export of vRNPs. The non-structural (NS1) protein is found in Influenzavirus A, Influenzavirus B, and Influenzavirus C. The non-structural (NS1) protein of the highly pathogenic avian H5N1 viruses circulating in poultry and waterfowl in Southeast Asia is currently believed to be responsible for the enhanced virulence of the strain. The Non-structural (NS1) protein of influenza A virus is a non-essential virulence factor that has multiple accessory functions during viral infection. The major role ascribed to NS1 has been its inhibition of host immune responses, especially the limitation of both interferon (IFN) production and the antiviral effects of IFN-induced proteins, such as dsRNA-dependent protein kinase R (PKR) and 2'5'-oligoadenylate synthetase (OAS)/RNase L. Non-structural (NS1) protein is a non-structural protein of the influenza A virus, which could only be expressed when cells are infected. The effect of NS1 protein on the host cell is still not clear. Not only could NS1 remarkably affect metabolism, but it could also slow down cell proliferation by blocking the cell cycle. Non-structural (NS1) protein may lead to the development of novel antiviral drugs, and the use of oncolytic influenza A viruses as potential anti-cancer agents.

    Nonstructural protein 1/NS1 References

    • Enami,M. et al., 1997, Nippon Rinsho. 55 (10):2605-9.
    • Bergmann,M. et al., 2000, J Virol. 74 (13):6203-6.
    • Hale,B.G. et al., 2008, J Gen Virol. 89 (Pt 10):2359-76.
    • Zhao,L. et al., 2008, Sheng Wu Gong Cheng Xue Bao. 24 (11):1912-7

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