Oncostatin M/OSM Proteins, Antibodies, cDNA Clones Research Reagents

OSM (Oncostatin M), located on 22q12.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 28484 Da protein composed of 252 amino acids. This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. Diseases such as Plasmacytoma and Cerebral Meningioma are associated with OSM. The related pathways of OSM include G-protein signaling Ras family GTPases in kinase cascades (scheme) and PEDF Induced Signaling.

Oncostatin M/OSM Protein (4)

    Oncostatin M/OSM Antibody (6)

      Oncostatin M/OSM cDNA Clone (26)

      NM_020530.3
      NM_001013365.1

      Oncostatin M/OSM Lysate (3)

        Oncostatin M/OSM Background

        Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Oncostatin M (OSM) is considered as a pleiotropic cytokine that signals through cell surface receptors typeⅠand typeⅡ both of which share the similarity of containing protein gp130 and takes part in many bio metabolism processes including liver development, hematopoiesis, inflammation, bone formation, and destruction and possibly CNS development. Oncostatin M (OSM) was previously identified by its ability to inhibit the growth of cells from melanoma and other solid tumors. It also has been reported that OSM, like LIF, IL-6, and G-CSF, can inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells. The human form of OSM is insensitive between pH2 and 11 and resistant to heating for one hour at 56 degrees but is not stable at 90 degrees. The human OSM is produced as a precursor containing 252 amino acids, whose first 25 amino acids function as a secretory signal peptide and which on removal yields the soluble 227 amino acid pro-OSM. Removal of the C-terminal most 31 amino acids produces the fully active 196 residue form.

        Oncostatin M/OSM References

        • Tanaka M, et al. (2003) Oncostatin M, a multifunctional cytokine. Rev Physiol Biochem Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 149: 39-52.
        • Auguste P, et al. (1997) Signaling of type II oncostatin M receptor. J Biol Chem. 272 (25): 15760-4.
        • Zarling JM, et al. (1986). Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells. Proc Natl Acad Sci. 83 (24): 9739-43.

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