OX40L/TNFSF4 Proteins, Antibodies, cDNA Clones Research Reagents

All OX40L/TNFSF4 reagents are produced in house and quality controlled, including 1 OX40L/TNFSF4 Antibody, 52 OX40L/TNFSF4 Gene, 5 OX40L/TNFSF4 Lysate, 6 OX40L/TNFSF4 Protein, 2 OX40L/TNFSF4 qPCR. All OX40L/TNFSF4 reagents are ready to use.

OX40L/TNFSF4 Protein (6)

    OX40L/TNFSF4 Antibody (1)

      OX40L/TNFSF4 cDNA Clone (52)


      OX40L/TNFSF4 Lysate (5)

        OX40L/TNFSF4 Background

        OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX40. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD4-stimulated B cells, this cytokine along with CD7 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.

        OX40L/TNFSF4 References

        • Lei W. et al., 2012, Ann Acad Med Singapore. 41 (5): 200-4.
        • Lee YH. et al., 2012, Hum Immunol. 73 (10): 1050-4.
        • Weiguang Y. et al., 2012, PLoS One. 7 (8): e41277.

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