OXCT1 Antibodies, cDNA Clones Research Reagents

OXCT1 (3-Oxoacid CoA-Transferase 1, also known as OXCT; SCOT), located on 5p13.1, is a Protein Coding gene. This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The gene produces a 56158 Da protein composed of 520 amino acids. OXCT1 is a mitochondrial matrix enzyme that functions as a homodimer. OXCT1 mRNA was most abundant in the heart and was also detectable in leukocytes and fibroblasts. Diseases such as Succinyl-Coa:3-Oxoacid-Coa Transferase Deficiency and Monocarboxylate Transporter 1 Deficiency are associated with OXCT1.

OXCT1 Antibody (1)

    OXCT1 cDNA Clone (31)

    NM_001127580.1

    In cloning vector

    OXCT1 Background

    Succinyl-CoA:3-oxoacid CoA transferase (SCOT, gene symbol OXCT1) deficiency is an autosomal recessive disorder in ketone body utilization that results in severe recurrent ketoacidosis episodes in infancy, including neonatal periods. 3-oxoacid CoA-transferase 1 (OXCT1) is a key enzyme in ketone body metabolism that catalyzes the first and rate-determining step of ketolysis and is expressed in adipose and other tissues. The product of OXCT1 converts to acetyl-CoA and finally fed into the tricarboxylic acid cycle for oxidation and ATP production. In the mitochondrial matrix, the OXCT1 gene catalyzes the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate in a reaction related to energy production from ketone bodies. OXCT1 may play a role in adipogenesis and provides new insight on adipose deposition in sheep.

    OXCT1 References

    • Zhang S, et al. (2017) The role of oxct1 in the pathogenesis of cancer as a rate-limiting enzyme of ketone body metabolism. Life Sci 183 110-115.
    • Sasai H, et al. (2017) Heterozygous carriers of succinyl-coa:3-oxoacid coa transferase deficiency can develop severe ketoacidosis. J Inherit Metab Dis 40 (6): 845-852.
    • Nam GH, et al. (2012) Identification of orf sequences and exercise-induced expression change in thoroughbred horse oxct1 gene. Gene 496 (1): 45-48.

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