PFTK1 Antibodies, cDNA Clones Research Reagents

CDK14 (Cyclin Dependent Kinase 14), located on human chromosome 7q21.13, is a member of the CDC2 (MIM 116940)-related protein kinase family. CDK14 is also known as PFTK1 and PFTAIRE1. The human CDK14 gene encodes a 53057 Da protein containing 469 amino acids. The CDK14 protein is ubiquitously expressed in brain, kidney and other tissues. Among its related pathways are Transcriptional misregulation in cancer. CDK14 is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. CDK15 is an important paralog of CDK14 gene.

PFTK1 Antibody (1)

    PFTK1 cDNA Clone (1)


    In expression vector

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    PFTK1 Background

    Cyclin-dependent kinases (CDKs) are perceived as the engine that drives cell cycle progression whereas cyclins are considered to be the gears that are changed to aid the transition between cycle phases. Cyclin-dependent kinase 14 (CDK14) is a cdc2-related serine/threonine protein kinase and plays an important role in normal cell cycle progression. CDK14 and other TAIRE family kinases (CDKs 15-18) are frequent off-targets of clinical kinase inhibitors. CDK14 has significant involvement in tumorigenesis of cancers including hepatocellular carcinoma, gastric carcinoma and breast cancer. In esophageal cancer, CDK14 is useful as a prognostic marker and as a predictor of response to chemotherapy.

    PFTK1 References

    • Li Q, et al. (2018) Microrna-613 impedes the proliferation and invasion of glioma cells by targeting cyclin-dependent kinase 14. Biomed Pharmacother 98 636-642.
    • Duan C, et al. (2015) Cdk14 contributes to reactive gliosis via interaction with cyclin y in rat model of spinal cord injury. J Mol Neurosci 57 (4): 571-579.
    • Chen L, et al. (2019) Cdk14 involvement in proliferation migration and invasion of esophageal cancer. Ann Transl Med 7 (22): 681.

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