Pleckstrin Proteins, Antibodies, cDNA Clones Research Reagents

PLEK (Pleckstrin) is a protein coding gene located on human chromosome 2p14. PLEK is also known as P47. The human PLEK gene encodes a 40125 Da protein containing 350 amino acids. The PLEK protein is biasedly expressed in bone marrow, lymph node and other tissues. Among its related pathways are Response to elevated platelet cytosolic Ca2+. PLEK is related to protein homodimerization activity and phosphatidylinositol-3,4-bisphosphate binding. PLEK2 is an important paralog of PLEK gene. PLEK is associated with some diseases, including Agammaglobulinemia, X-Linked and Aarskog-Scott Syndrome.

Pleckstrin Protein (1)

    Pleckstrin Antibody (3)

      Pleckstrin cDNA Clone (15)

      Pleckstrin qPCR Primer (1)

      Pleckstrin Background

      Pleckstrin is a protein found in platelets. Pleckstrin is the source of the name pleckstrin homology domain. Pleckstrin homology domain (PH domain) is a protein domain of approximately 12 amino acids that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton. This domain can bind Phosphatidylinositol lipids within biological membranes (such as Phosphatidylinositol (3,4,5)-trisphosphate and phosphatidylinositol (4,5)-bisphosphate), and proteins such as the βγ-subunits of heterotrimeric G proteins, and protein kinase C. Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways.

      Pleckstrin References

      • Ingley E, et al. (1994) Pleckstrin homology (PH) domains in signal transduction. J Cell Biochem. 56(4):436-43.
      • Gibson TJ, et al. (1994) PH domain: the first anniversary. Trends Biochem Sci. 19(9):349-53.
      • Haslam RJ, et al. (1993) Pleckstrin domain homology. Nature. 363(6427):309-10.

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